Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype

Figure 3

Main proteomic changes of hepatocytes and LSECs upon A2aR stimulation and/or hepatic ischemia/reperfusion. Mice liver exposure to ischemia/reperfusion (I/R) downmodulates proteins associated with glucidic, lipid, and mitochondrial metabolism in hepatocytes and LSECs and, specifically in LSECs, with stress response. These proteins or proteins associated with the same processes are restored or upregulated in both hepatocytes and LSECs, upon A2aR stimulation after mice in vivo treatment with the A2aR agonist CGS21680. (See also text and [52].)