Integrating Retrogenesis Theory to Alzheimer’s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity

<div>DTI changes are evidenced in Alzheimer subjects when compared with healthy controls. Overlapping areas of FA decreased/DR increased are indicative of increased diffusion perpendicular to fibre orientation, possibly due to myelin breakdown (yellow-red). These areas can be observed in the corpus callosum (anterior and middle segments), anterior cingulum, and uncinate fasciculus (anterior portion) and remain when adjusting for group differences in gray matter atrophy (a) and white matter burden volume (c). Notes: FA: fractional anisotropy; DR: radial diffusivity.</div>

BioMed Research International

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Figure 2: Integrating Retrogenesis Theory to Alzheimer’s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity 

Figure 2 | Integrating Retrogenesis Theory to Alzheimer’s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity 