The Quantified Level of Circulating Prostate Stem Cell Antigen mRNA relative to GAPDH Level Is a Clinically Significant Indictor for Predicting Biochemical Recurrence in Prostate Cancer Patients after Radical Prostatectomy
Table 2
Correlation of prostate stem cell antigen titer with known clinicopathological prognostic parameters ( = 110).
Parameters
Correlation with PSCA absolute titer ( value)
Correlation with PSCA/GAPDH ( value)
Age (years)
0.601
0.685
Preoperative PSA (ng/mL)
0.457
0.639
Preoperative-free PSA (ng/DL)
0.357
0.458
Prostate size (mL)
0.458
0.385
Gleason score sum at biopsy
0.508
0.741
Clinical T stage (T1, T2, ≥T3)
0.010 (OR 15.049)
0.485
Positive resection margin
0.018 (OR 9.545)
0.125
Pathologic Gleason score sum
0.630
0.571
Pathologic T stage (≤T2b or ≥T2c)
0.033 (OR 8.431)
0.187
Pathologic N or M stage
0.234
0.259
Apex involvement
0.003 (OR 13.291)
0.643
Lymphovascular invasion
0.643
0.053 (OR 7.934)
Perineural invasion
0.059 (OR 7.419)
0.039 (OR 8.233)
Extracapsular extension
0.051 (OR 7.658)
0.108
Seminal vesicle invasion
0.810
0.950
Biochemical recurrence
0.681
0.032 (OR 8.091)
OR: odds ratio; HGPIN: high grade prostatic intraepithelial neoplasm; PSA: prostatic specific antigen.
