Table 1: Summary of studies on carotid contrast-enhanced ultrasound (CEUS) for the detection of intraplaque neovascularization. The results of each study are expressed with the statistical significance ( value) of the correlation between the parameters.

Author Year  Number of patients Symptomatic Asymptomatic Histology Contrast agent Ultrasound apparatus Vascular probe Mechanical indexCEUS analysisResults
Semiautomated analysisVisual assessmentCEUS and histologyCEUS and carotid symptomsCEUS and echogenicityCEUS and other vulnerable characteristicsCEUS and genderSoftware and visual assessment

Li et al. [9]2014171341SonoVuePhilips iU-22 ultrasound system L 9-30,07110,00200000

Hjelmgren et al. [10]201413760SonoVueSiemens S2000 systemL 9-40,061100,050,01000,001

Kim et al. [11]2014890891SonoVueAcuson Sequoia 512 Siemens systemL 15-80,19010,02100000

van den Oord et al. [12]201414301430SonoVuePhilips iU-22 ultrasound system L 9-30,06–0,081100000,030

Müller et al. [13]20143317161SonoVueAntares Siemens systemnnnn110,01Not significant0000,02

Vavuranakis et al. [14] 2013140141SonoVueAcuson Sequoia 512 Siemens systemL 15-8nn100,00200000

Ritter et al. [15]2013414100SonoVueGE Logiq 7 systemL 9-3nn010000,0200

Hjelmgren et al. [16]20135210420SonoVueSiemens S2000 systemL 9-40,06100Not significant0,02000

van den Oord et al. [17]2013690690SonoVuePhilips iU-22 ultrasound system L 9-30,06–0,08110000,0500

Zhou et al. [18]20134624220SonoVueAcuson Sequoia 512 Siemens systemL 20,07010Not significant00,0500

Varetto et al. [19]20125112391SonoVueEsaote MyLab 25 Gold systemL 9-2nn100,0010,010,02000

Faggioli et al. [20]2011227151SonoVuePhilips iU-22 ultrasound system L 9-30.13100,0030,0060000

Hoogi et al. [21]2011278191DefinityPhilips iU-22 ultrasound system L 8-4100,0100000

Shalhoub et al. [22]20113116151SonoVuePhilips iU-22 ultrasound system L 12-50,34100,00400000

Owen et al. [23]20103716210SonoVuePhilips iU-22 ultrasound system L 12-50,341000,0050000

Huang et al. [24]201018386970SonoVueAcuson Sequoia 512 Siemens systemL 15-80,351100,0010000,001

Staub et al.
[25]
2010147171300DefinityATL HDI 5000 Philips system L 7-40,06–0,1010000,03400

Giannoni et al. [26]2009776491SonoVueAcuson Sequoia 512 Siemens systemL 9-30,4–1,411>0,050,0010,001000

Magnoni et al. [27]2009250250OptisonGE Vivid 7 systemL 7 0,08–01010000,00100

Xiong et al. [28]200910435690SonoVueGE Logiq 9 systemL 9-30,131000,0010000

Huang et al. [29]2008630630SonoVueAcuson Sequoia 512 Siemens systemL 15-80,3510000,01000

Coli et al. [30]2008322841OptisonGE Vivid 7 systemL 7 0,08–0,1010,0050,001000

Vicenzini et al. [31]2007230231SonoVueAcuson Sequoia 512 Siemens systemL 6-150,4–1,401>0,050>0,05>0,0500

Shah et al. [32]2007175121OptisonATL HDI 5000 Philips system L 7-40,06–0,1010,00200000

Total1356406946121615