Decreased Splenic T-Lymphocytes in Apolipoprotein M Gene Deficient Mice

Figure 4

Serum protein levels of TNF-alpha and MCP-1 in apoM^−/− mice and apoM^+/+ mice with or without LPS treatment. (a) The serum levels of TNF-alpha in both apoM^+/+ and apoM^−/− mice were significantly increased after LPS treatment. (b) The basal MCP-1 levels were higher in apoM^−/− mice than in apoM^+/+ mice. After LPS treatment, serum levels of MCP-1 were dramatically increased in both apoM^+/+ and apoM^−/− mice, but there were no statistical differences between apoM^−/− mice and apoM^+/+ mice (, one-way ANOVA followed by Dunnett’s test, , , and versus apoM^+/+ or apoM^−/− control; Mann-Whitney test, and ).

(a)

(b)