Effect of Long-Term Treatment with Fimasartan on Transient Focal Ischemia in Rat Brain
Immunofluorescent staining of inflammatory cells and western blot analyses. (a) Ox6-stained microglia/macrophages (green) were less frequently found in the periphery of the lesion, and the density in the fimasartan-treated group was lower than the PBS-control with MCAO group ( each). Scale bar = 50 μm. (b) According to the quantitative analysis, the fimasartan-injected group exhibited a lower number of Ox6+ cells () compared to the PBS-control with MCAO group. (c) At 48 hours after ischemia induction, the density of IκB increased and cyclooxygenase-2 (COX-2) decreased in the fimasartan-treated group compared with the PBS-control with MCAO group ( each). (d) In the quantitative analyses, the degradation of IκB was suppressed in the low-dose fimasartan-treated group in the lesion and was comparable to the contralateral brain in the PBS-control with MCAO group compared with lesion side in the PBS-control with MCAO group (). (e) The density of COX-2 in the infarcted hemisphere was 1.6-fold higher in the PBS-control with MCAO group compared to the fimasartan-treated group ().
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