Research Article
Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population
Table 2
The odds ratio (OR) of the miRNA processing genes single nucleotide polymorphisms in head and neck cancer patients and healthy controls.
| Gene/rs number | Genotype |
Controls number |
Patients number | Odds ratio |
0.95 confidence intervals | | (0.95 CI) | Lower limit | Upper limit |
| DROSHA | 6877842 | CC | 15 | 6 | Ref. | | | | CG | 79 | 49 | 1.5506 | 0.5638 | 4.2644 | 0.392883 | GG | 76 | 73 | 2.4013 | 0.8836 | 6.526 | 0.078775 |
| DICER1 | 3742330 | AA | 63 | 23 | Ref. | | | | AG | 103 | 100 | 2.6593 | 1.5326 | 4.6144 | 0.0004 | GG | 4 | 0 | NA | | | | 13078 | AA | 10 | 7 | Ref. | | | | AT | 124 | 46 | 0.53 | 0.1904 | 1.4747 | 0.17013F | TT | 36 | 75 | 2.9762 | 1.0473 | 8.4579 | 0.034697 |
| DGCR8 | 1640299 | GG | 16 | 6 | Ref. | | | | GT | 93 | 47 | 1.3477 | 0.4949 | 3.6696 | 0.559829 | TT | 61 | 60 | 2.623 | 0.9614 | 7.1562 | 0.053443 | 3757 | AA | 15 | 4 | Ref. | | | | AG | 119 | 89 | 2.8046 | 0.9 | 8.74 | 0.065196 | GG | 36 | 29 | 3.0208 | 0.9039 | 10.0951 | 0.064411 | 417309 | AA | 8 | 13 | Ref. | | | | AG | 46 | 32 | 0.4281 | 0.1591 | 1.1516 | 0.088032 | GG | 116 | 67 | 0.3554 | 0.1401 | 0.9015 | 0.024484 |
| RAN | 14035 | CC | 67 | 73 | Ref. | | | | CT | 93 | 32 | 0.3158 | 0.1876 | 0.5317 | <0.0001 | TT | 10 | 5 | 0.4589 | 0.1492 | 1.4115 | 0.165857 |
| TARBP2 | 784567 | AA | 35 | 7 | Ref. | | | | AG | 114 | 70 | 3.0702 | 1.2935 | 7.2871 | 0.008335 | GG | 21 | 51 | 12.1429 | 4.661 | 31.6345 | <0.0001 |
| XPO5 | 11077 | GG | 82 | 26 | Ref. | | | | GT | 44 | 62 | 4.4441 | 2.4723 | 7.9883 | <0.0001 | TT | 34 | 36 | 3.3394 | 1.7544 | 6.3563 | 0.000183 |
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