Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population

Table 3

An association of the miRNA processing genes single nucleotide polymorphisms with tumor stage of head and neck cancer.

(a)

Gene/rs number	Genotype	Controls; number	T1					T2
			Patients	Odds ratio	0.95 confidence intervals			Patients	Odds ratio	0.95 confidence intervals
			number		Lower limit	Upper limit		number		Lower limit	Upper limit
DROSHA
6877842	CC	15	1	Ref.				0	Ref.
	CG	79	5	0.9494	0.1034	8.7141	0.6590^F	6	NA
	GG	76	4	0.7595	0.0793	7.2769	0.5940^F	11	NA
DICER1
3742330	AA	63	1	Ref.				3	Ref.
	AG	103	8	4.8932	0.5978	40.0546	0.0967^F	12	2.4466	0.6645	9.0082	0.1669
	GG	4	0	NA				0	NA
13078	AA	10	0	Ref.				1	Ref.
	AT	124	8	NA				8	0.6452	0.0732	5.6871	0.5239^F
	TT	36	2	NA				8	2.2222	0.2478	19.9312	0.4181^F
DGCR8
1640299	GG	16	0	Ref.				1	Ref.
	GT	93	2	NA				9	1.5652	0.1854	13.2126	0.5614^F
	TT	61	4	NA				5	1.3115	0.1429	12.0333	0.6432^F
3757	AA	15	1	Ref.				0	Ref.
	AG	119	7	0.8824	0.1014	7.6744	0.6255^F	15	NA
	GG	36	1	0.4167	0.0244	7.107	0.5166^F	2	NA
417309	AA	8	4	Ref.				2	Ref.
	AG	46	2	0.087	0.0136	0.5564	0.0119^F	8	0.6957	0.1243	3.892	0.4909^F
	GG	116	3	0.0517	0.0098	0.2719	0.0012^F	5	0.1724	0.0288	1.0322	0.0898^F
RAN
14035	CC	67	7	Ref.				9	Ref.
	CT	93	2	0.2058	0.0415	1.0221	0.0383^F	6	0.4803	0.1632	1.4139	0.1761
	TT	10	1	0.9571	0.1063	8.6223	0.7245^F	0	NA
TARBP2
784567	AA	35	1	Ref.				1	Ref.
	AG	114	6	1.8421	0.2144	15.8246	0.4907^F	8	2.4561	0.2969	20.3221	0.3494^F
	GG	21	2	3.3333	0.2846	39.0437	0.3346^F	8	13.3333	1.556	114.2517	0.0051^F
XPO5
11077	GG	82	2	Ref.				3	Ref.
	GT	44	4	3.7273	0.6565	21.1609	0.1274^F	8	4.9697	1.2546	19.686	0.0167^F
	TT	34	3	3.6176	0.5784	22.6277	0.1663^F	5	4.0196	0.9094	17.7671	0.0634^F

values calculated with Fisher’s exact probability test.

(b)

Gene/rs number	Genotype	T3						T4
		Controls	Patients	Odds ratio	0.95 confidence intervals			Controls	Patients	Odds ratio	0.95 confidence intervals
		number	number		Lower limit	Upper limit		number	number		Lower limit	Upper limit
DROSHA
6877842	CC	15	4	Ref.				15	1	Ref.
	CG	79	17	0.807	0.238	2.7364	0.4730^F	79	21	3.9873	0.4978	31.9386	0.1440^F
	GG	76	32	1.5789	0.4863	5.127	0.4424	76	26	5.1316	0.6458	40.776	0.0747^F
DICER1
3742330	AA	63	11	Ref.				63	8	Ref.
	AG	103	40	2.2242	1.0641	4.649	0.0308	103	40	3.0583	1.3452	6.9527	0.0058
	GG	4	0	NA				4	0	NA
13078	AA	10	3	Ref.				10	3	Ref.
	AT	124	15	0.4032	0.0997	1.6304	0.1859^F	124	15	0.4032	0.0997	1.6304	0.1859^F
	TT	36	35	3.2407	0.8222	12.7733	0.0807	36	30	2.7778	0.7001	11.0216	0.1345
DGCR8
1640299	GG	16	2	Ref.				16	3	Ref.
	GT	93	23	1.978	0.4245	9.2218	0.3022^F	93	13	0.7455	0.1908	2.9131	0.4531
	TT	61	27	3.541	0.7605	16.4881	0.0739	61	24	2.0984	0.5603	7.8588	0.2067
3757	AA	15	3	Ref.				15	0	Ref.
	AG	119	34	1.4286	0.3905	5.2255	0.4235^F	119	34	NA
	GG	36	15	2.0833	0.5251	8.2662	0.2317^F	36	11	NA
417309	AA	8	3	Ref.				8	4	Ref.
	AG	46	13	0.7536	0.1745	3.2541	0.4838^F	46	9	0.3913	0.0968	1.5817	0.1704^F
	GG	116	28	0.6437	0.1604	2.5833	0.3825^F	116	31	0.5345	0.151	1.8918	0.2557^F
RAN
14035	CC	67	33	Ref.				67	24	Ref.
	CT	93	11	0.2401	0.1133	0.509	<0.0001	93	13	0.3902	0.1854	0.8216	0.0114
	TT	10	3	0.6091	0.157	2.3634	0.3528^F	10	1	0.2792	0.0339	2.2978	0.1914^F
TARBP2
784567	AA	35	4	Ref.				35	1	Ref.
	AG	114	31	2.3794	0.7857	7.2059	0.1160	114	25	7.6754	1.0036	58.6983	0.0222
	GG	21	19	7.9167	2.3694	26.4517	0.00027	21	22	36.6667	4.6001	292.2647	<0.0001
XPO5
11077	GG	82	10	Ref.				82	11	Ref.
	GT	44	26	4.8455	2.1424	10.9591	<0.0001	44	24	4.0661	1.8231	9.0689	0.000364
	TT	34	16	3.8588	1.5918	9.3545	0.001873	34	12	2.631	1.0584	6.5403	0.033306

values calculated  with Fisher’s exact probability test.