Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population

Table 4

An association of the miRNA processing genes single nucleotide polymorphisms with lymph node metastases occurrence in head and neck cancer.

Gene/rs number	Genotype	Controls; number	N0					N1–3					N1–3 versus N0
			Patients	Odds ratio	0.95 confidence intervals			Patients	Odds ratio	0.95 confidence intervals			Odds ratio	0.95 confidence intervals
			Number		Lower limit	Upper limit		number		Lower limit	Upper limit			Lower limit	Upper limit
DROSHA
6877842	CC	15	6	Ref.				0	Ref.				Ref.
	CG	79	36	1.1392	0.4085	3.1769	0.8064	13	NA				NA
	GG	76	51	1.6776	0.6104	4.611	0.3125	22	NA				NA
DICER1
3742330	AA	63	18	Ref.				5	Ref.				Ref.
	AG	103	71	2.6041	1.4276	4.7502	0.0014	29	3.5476	1.3057	9.6388	0.0091	1.4704	0.4989	4.3338	0.4839
	GG	4	0	NA				0	NA				NA
13078	AA	10	4	Ref.				3	Ref.				Ref.
	AT	124	38	0.7661	0.2273	2.5825	0.4394^F	8	0.2151	0.0492	0.9401	0.0612^F	0.2807	0.0523	1.506	0.1470^F
	TT	36	52	3.6111	1.0503	12.416	0.0331	23	2.1296	0.5292	8.5696	0.2263^F	0.5897	0.122	2.85	0.3904^F
DGCR8
1640299	GG	16	5	Ref.				1	Ref.				Ref.
	GT	93	34	4.4602	1.6527	12.0368	0.0016	13	8.5269	1.0874	66.8658	0.0159	1.911	0.2035	17.9611	0.493^F
	TT	61	43	32.787	11.1638	96.2956	<0.0001	17	64.812	8.0116	524.3237	<0.0001	1.976	0.2148	18.1876	0.474^F
3757	AA	15	4	Ref.				0	Ref.				Ref.
	AG	119	63	1.9853	0.6321	6.2352	0.2334	26	NA				NA
	GG	36	23	2.3958	0.7068	8.1213	0.1532	6	NA				NA
417309	AA	8	11	Ref.				2	Ref.				Ref.
	AG	46	25	0.4427	0.1589	1.2335	0.1138	7	0.6087	0.1067	3.4736	0.4382^F	1.54	0.2746	8.6355	0.4822^F
	GG	116	49	0.3072	0.1165	0.8104	0.0131	18	0.6207	0.122	3.1588	0.4176^F	2.0204	0.4077	10.013	0.3118^F
RAN
14035	CC	67	51	Ref.				22	Ref.				Ref.
	CT	93	28	0.3955	0.2264	0.6909	0.0009	4	0.131	0.0431	0.3977	<0.0001	0.3312	0.1037	1.0573	0.0541
	TT	10	4	0.5255	0.1559	1.7718	0.2942	1	0.3045	0.0369	2.5153	0.2253	0.5795	0.0612	5.4857	0.5363
TARBP2
784567	AA	35	7	Ref.				0	Ref.				Ref.
	AG	114	50	2.193	0.9124	5.2711	0.0741	20	NA				NA
	GG	21	36	8.5714	3.2371	22.6961	<0.0001	15	NA				NA
XPO5
11077	GG	82	19	Ref.				7	Ref.				Ref.
	GT	44	43	4.2177	2.1965	8.099	<0.0001	19	5.0584	1.9743	12.9602	0.0003	1.1993	0.432	3.3294	0.7290
	TT	34	28	3.5542	1.7534	7.2043	0.0003	8	2.7563	0.9264	8.2008	0.0599^F	0.7755	0.2407	2.4981	0.6713

values calculated with Fisher’s exact probability test.