Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population

Table 5

An association of the miRNA processing genes single nucleotide polymorphisms with stage of larynx cancer.

(a)

Gene/rs number	Genotype	Controls; number	Stage I					Stage II
			Patients	Odds ratio	0.95 confidence intervals			Patients	Odds ratio	0.95 confidence intervals
			number		Lower limit	Upper limit		number		Lower limit	Upper limit
DROSHA
6877842	CC	15	1	Ref.				0	Ref.
	CG	79	5	0.9494	0.1034	8.7141	0.6590	3	NA
	GG	76	4	0.7895	0.0824	7.5674	0.6067	5	NA
DICER1
3742330	AA	63	1	Ref.				2	Ref.
	AG	103	8	4.8932	0.5978	40.0546	0.0967	4	1.2233	0.2177	6.8735	0.5907
	GG	4	0	NA				0	NA
13078	AA	10	0	Ref.				1	Ref.
	AT	124	8	NA				6	0.4839	0.0529	4.4237	0.4409
	TT	36	2	NA				1	0.2778	0.0159	4.8457	0.4095
DGCR8
1640299	GG	16	0	Ref.				0	Ref.
	GT	93	2	NA				6	NA
	TT	61	4	NA				2	NA
3757	AA	15	1	Ref.				0	Ref.
	AG	119	7	0.8824	0.1014	7.6744	0.6255	6	NA
	GG	36	1	0.4167	0.0244	7.107	0.5166	2	NA
417309	AA	8	4	Ref.				1	Ref.
	AG	46	2	0.087	0.0136	0.5564	0.0119	4	0.6957	0.0686	7.0533	0.5767
	GG	116	3	0.0517	0.0098	0.2719	0.0012	2	0.1379	0.0113	1.689	0.1993
RAN
14035	CC	67	7	Ref.				2	Ref.
	CT	93	2	0.2058	0.0415	1.0221	0.0383	5	1.8011	0.3392	9.5644	0.3884
	TT	10	1	0.9571	0.1063	8.6223	0.7245	0	NA
TARBP2
7845672	AA	35	1	Ref.				0	Ref.
	AG	114	6	1.8421	0.2144	15.8246	0.4907	3	NA
	GG	21	2	3.3333	0.2846	39.0437	0.3346	5	NA
XPO5
11077	GG	82	2	Ref.				1	Ref.
	GT	44	4	3.7273	0.6565	21.1609	0.1274	4	7.4545	0.8082	68.7565	0.06
	TT	34	3	3.6176	0.5784	22.6277	0.1663	3	7.2353	0.7267	72.0402	0.0865

All values are for Fisher’s exact probability test due to low sample sizes.

(b)

Gene/rs number	Genotype	Controls; number	Stage III					Stage IV
			Patients	Odds ratio	0.95 confidence intervals			Patients	Odds ratio	0.95 confidence intervals
			number		Lower limit	Upper limit		number		Lower limit	Upper limit
DROSHA
6877842	CC	15	4	Ref.				1	Ref.
	CG	79	16	0.7595	0.2227	2.5903	0.4371^F	24	4.557	0.572	36.3009	0.1034^F
	GG	76	31	1.5296	0.4703	4.9749	0.4795	33	6.5132	0.8259	51.3637	0.0341^F
DICER1
3742330	AA	63	10	Ref.				10	Ref.
	AG	103	38	2.3243	1.0828	4.9893	0.0276	49	2.9971	1.4173	6.3378	0.0031
	GG	4	0	NA				0	NA
13078	AA	10	1	Ref.				4	Ref.
	AT	124	14	1.129	0.1344	9.4878	0.6945^F	17	0.3427	0.0967	1.215	0.1004^F
	TT	36	33	9.1667	1.1122	75.5513	0.01450^F	38	2.6389	0.7591	9.1733	0.1006^F
DGCR8
1640299	GG	16	2	Ref.				4	Ref.
	GT	93	21	1.8065	0.3856	8.4634	0.3533^F	18	0.0968	0.0165	0.5686	0.0112^F
	TT	61	26	3.4098	0.731	15.9056	0.0836^F	26	0.5	0.0841	2.9719	0.3691^F
3757	AA	15	2	Ref.				0	Ref.
	AG	119	33	2.0798	0.4526	9.5571	0.2709^F	42	NA
	GG	36	10	2.0833	0.4068	10.6686	0.3073^F	11	NA
417309	AA	8	4	Ref.				3	Ref.
	AG	46	13	0.5652	0.1467	2.178	0.3094^F	13	0.7536	0.1745	3.2541	0.4838^F
	GG	116	25	0.431	0.1204	1.5436	0.1704^F	35	0.8046	0.2025	3.1973	0.4996^F
RAN
14035	CC	67	32	Ref.				29	Ref.
	CT	93	11	0.2476	0.1166	0.5262	0.0001	14	0.3478	0.1708	0.7081	0.0028
	TT	10	3	0.6281	0.1617	2.4405	0.3715^F	1	0.231	0.0283	1.8892	0.1277^F
TARBP2
784567	AA	35	5	Ref.				1	Ref.
	AG	114	28	1.7193	0.6174	4.788	0.2942	32	9.8246	1.2953	74.5144	0.0075
	GG	21	18	6	1.9403	18.5537	0.0009	26	43.3333	5.4718	343.1724	<0.0001
XPO5
11077	GG	82	9	Ref.				13	Ref.
	GT	44	24	4.9697	2.1259	11.6175	<0.0001	29	4.1573	1.9643	8.799	0.0001
	TT	34	16	4.2876	1.7271	10.644	0.001	14	2.5973	1.1054	6.1026	0.0254

values calculated with Fisher’s exact probability test.