Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes

Table 1

Main classes of molecular chaperones.

Family name	Functions
HSP100	Unfolding, solubilisation of aggregates, proteolysis
HSP90	Protein maturation of steroid receptors, protein kinases, and other components of cellular signalling pathways. Organelle-specific variants exist
HSP70	Nascent-protein folding, refolding of denatured proteins, and translocation across membranes. Organelle-specific variants exist
HSP60/chaperonins	Protein folding and prevention of aggregation (bacterial and mitochondrial proteins)
CCT (TRiC)	Folding of cytoskeleton components
HSP40	Hsp70 ATPase activators and intrinsic chaperone activity
Small HSPs (sHSPs)	Prevention of aggregation, probable role in membrane homeostasis