Low Mutational Burden of Eight Genes Involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 Pathways in Female Genital Tract Primary Melanomas

Table 1

Clinicopathological characteristics of the 16 female genital tract primary melanomas.

Patient number	Age	Race	Primary	Location	Melanoma family history	Nodal metastasis	Stage	Breslow depth	Pigmentation	Histology type	Growth phase
1	42	White	Yes	Cervix	No	No	IB1	V	Positive	Mucosal on nevi	Vertical
2	55	White	Yes	Cervix	No	No	IA2	V	Positive	Superficial spreading	Focal vertical
3	34	White	Yes	Clitoris	No	No	IIB	IV	Positive	Mucosal lentiginous	Vertical
4	75	White	Yes	Clitoris	No	No	IIA	III	Positive	Mucosal desmoplastic	Not available
5	53	White	Yes	Clitoris	No	Lung	IIB	V	Positive	Nodular	Vertical
6	86	White	Yes	Vagina	No	No	IIC	V	Positive	Nodular	Vertical
7	95	White	Yes	Vagina	No	No	IB	I	Positive	Mucosal lentiginous	Vertical
8	60	White	Yes	Vagina	No	No	IIA	V	Positive	Nodular	Vertical
9	68	White	Yes	Vagina	No	No	IIC	V	Positive	Nodular	Vertical
10	52	White	Yes	Vulva	No	Nodes	IA	I	Positive	Superficial spreading	Focal vertical
11	64	White	Yes	Vulva	No	No	IIC	V	Positive	Superficial spreading	Focal vertical
12	48	White	Yes	Vulva	No	Nodes and leg	IIIB	V	Positive	Nodular	Vertical
13	44	White	Yes	Vulva	No	No	IIA	II	Positive	Superficial spreading	Not available
14	66	White	Yes	Vulva	No	Nodes	IIIB	II	Positive	Nodular; Pagetoid	Vertical
15	70	White	Yes	Vulva	No	Nodes	IA	I	Positive	Superficial spreading	Not available
16	85	White	Yes	Vulva	No	No	IIC	V	Positive	Mucosal lentiginous	Vertical