PVT1: A Rising Star among Oncogenic Long Noncoding RNAs

Figure 5

The PVT1 functions. (a) Model of PVT1 ceRNA mechanism operating in normal breast but not in breast cancer tissues possibly due to a prevalence in cancer of expression of PVT1 isoforms lacking recognition elements for the miRNA to be sponged, as it has been hypothesized for the case of mir-200 family based on sequence analysis of alternative PVT1 isoforms [21]. (b) Model of PVT1 positive regulation of the MYC protein stability by rescuing MYC from phosphorylation [87]. This figure is inspired by [87]. (c) The proposed model of TGF/PVT1/NOP2 regulatory network [41]: TGF promotes the interaction between PVT1 and NOP2 that in turn activates proliferation, cell cycle, and TGF signalling pathways. The sketches of yellow switches in the figure symbolize the pathway activation.

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