Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 304575, 9 pages
http://dx.doi.org/10.1155/2015/304575
Research Article

Gold Nanoparticles Promote Oxidant-Mediated Activation of NF-κB and 53BP1 Recruitment-Based Adaptive Response in Human Astrocytes

1Department of Genetics, University of Rzeszow, Rejtana 16C, 35-959 Rzeszow, Poland
2Department of Biochemistry and Cell Biology, University of Rzeszow, Zelwerowicza 4, 35-601 Rzeszow, Poland
3Department of Plant Physiology, University of Rzeszow, Werynia 502, 36-100 Kolbuszowa, Poland

Received 6 May 2015; Accepted 11 June 2015

Academic Editor: Jinsong Ren

Copyright © 2015 Jennifer Mytych et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Khlebtsov and L. Dykman, “Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies,” Chemical Society Reviews, vol. 40, no. 3, pp. 1647–1671, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. R. A. Sperling, P. Rivera Gil, F. Zhang, M. Zanella, and W. J. Parak, “Biological applications of gold nanoparticles,” Chemical Society Reviews, vol. 37, no. 9, pp. 1896–1908, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Ghosh, G. Han, M. De, C. K. Kim, and V. M. Rotello, “Gold nanoparticles in delivery applications,” Advanced Drug Delivery Reviews, vol. 60, no. 11, pp. 1307–1315, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. R. Kanwar, X. Sun, V. Punj et al., “Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 8, no. 4, pp. 399–414, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Gromnicova, H. A. Davies, P. Sreekanthreddy et al., “Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro,” PLoS ONE, vol. 8, no. 12, Article ID e81043, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Wohlfart, S. Gelperina, and J. Kreuter, “Transport of drugs across the blood-brain barrier by nanoparticles,” Journal of Controlled Release, vol. 161, no. 2, pp. 264–273, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. E. E. Connor, J. Mwamuka, A. Gole, C. J. Murphy, and M. D. Wyatt, “Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity,” Small, vol. 1, no. 3, pp. 325–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. A. M. Alkilany and C. J. Murphy, “Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?” Journal of Nanoparticle Research, vol. 12, no. 7, pp. 2313–2333, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Oberdörster, A. Elder, and A. Rinderknecht, “Nanoparticles and the brain: cause for concern?” Journal of Nanoscience and Nanotechnology, vol. 9, no. 8, pp. 4996–5007, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Pan, S. Neuss, A. Leifert et al., “Size-dependent cytotoxicity of gold nanoparticles,” Small, vol. 3, no. 11, pp. 1941–1949, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. Q. Zhang, V. M. Hitchins, A. M. Schrand, S. M. Hussain, and P. L. Goering, “Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators,” Nanotoxicology, vol. 5, no. 3, pp. 284–295, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. K. B. Male, B. Lachance, S. Hrapovic, G. Sunahara, and J. H. T. Luong, “Assessment of cytotoxicity of quantum dots and gold nanoparticles using cell-based impedance spectroscopy,” Analytical Chemistry, vol. 80, no. 14, pp. 5487–5493, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. C. J. Gannon, C. R. Patra, R. Bhattacharya, P. Mukherjee, and S. A. Curley, “Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells,” Journal of Nanobiotechnology, vol. 6, article 2, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. P. J. Chueh, R.-Y. Liang, Y.-H. Lee, Z.-M. Zeng, and S.-M. Chuang, “Differential cytotoxic effects of gold nanoparticles in different mammalian cell lines,” Journal of Hazardous Materials, vol. 264, pp. 303–312, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. S.-M. Chuang, Y.-H. Lee, R.-Y. Liang et al., “Extensive evaluations of the cytotoxic effects of gold nanoparticles,” Biochimica et Biophysica Acta: General Subjects, vol. 1830, no. 10, pp. 4960–4973, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Pan, A. Leifert, D. Ruau et al., “Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage,” Small, vol. 5, no. 18, pp. 2067–2076, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Coradeghini, S. Gioria, C. P. García et al., “Size-dependent toxicity and cell interaction mechanisms of gold nanoparticles on mouse fibroblasts,” Toxicology Letters, vol. 217, no. 3, pp. 205–216, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Mironava, M. Hadjiargyrou, M. Simon, V. Jurukovski, and M. H. Rafailovich, “Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time,” Nanotoxicology, vol. 4, no. 1, pp. 120–137, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. F. Rahman, J. Wang, T. A. Patterson et al., “Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles,” Toxicology Letters, vol. 187, no. 1, pp. 15–21, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Söderstjerna, P. Bauer, T. Cedervall et al., “Silver and gold nanoparticles exposure to in vitro cultured retina—studies on nanoparticle internalization, apoptosis, oxidative stress, glial- and microglial activity,” PLoS ONE, vol. 9, no. 8, Article ID e105359, 2014. View at Publisher · View at Google Scholar
  21. F. Koch, A.-M. Möller, M. Frenz, U. Pieles, K. Kuehni-Boghenbor, and M. Mevissen, “An in vitro toxicity evaluation of gold-, PLLA- and PCL-coated silica nanoparticles in neuronal cells for nanoparticle-assisted laser-tissue soldering,” Toxicology in Vitro, vol. 28, no. 5, pp. 990–998, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Haase, S. Rott, A. Mantion et al., “Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses,” Toxicological Sciences, vol. 126, no. 2, pp. 457–468, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. N. J. Siddiqi, M. A. K. Abdelhalim, A. K. El-Ansary, A. S. Alhomida, and W. Y. Ong, “Identification of potential biomarkers of gold nanoparticle toxicity in rat brains,” Journal of Neuroinflammation, vol. 9, article 123, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Dworak, M. Wnuk, J. Zebrowski, G. Bartosz, and A. Lewinska, “Genotoxic and mutagenic activity of diamond nanoparticles in human peripheral lymphocytes in vitro,” Carbon, vol. 68, pp. 763–776, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Lewinska, J. Adamczyk, J. Pajak et al., “Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells,” Mutation Research, vol. 771, pp. 43–52, 2014. View at Publisher · View at Google Scholar
  26. J. Mytych, A. Lewinska, A. Bielak-Zmijewska, W. Grabowska, J. Zebrowski, and M. Wnuk, “Nanodiamond-mediated impairment of nucleolar activity is accompanied by oxidative stress and DNMT2 upregulation in human cervical carcinoma cells,” Chemico-Biological Interactions, vol. 220, pp. 51–63, 2014. View at Publisher · View at Google Scholar
  27. G. P. Dimri, X. Lee, G. Basile et al., “A biomarker that identifies senescent human cells in culture and in aging skin in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 20, pp. 9363–9367, 1995. View at Publisher · View at Google Scholar · View at Scopus
  28. J. P. D. Magalhães and G. M. Church, “Cells discover fire: employing reactive oxygen species in development and consequences for aging,” Experimental Gerontology, vol. 41, no. 1, pp. 1–10, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Bartosz, “Reactive oxygen species: destroyers or messengers?” Biochemical Pharmacology, vol. 77, no. 8, pp. 1303–1315, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Esposito, R. Ammendola, R. Faraonio, T. Russo, and F. Cimino, “Redox control of signal transduction, gene expression and cellular senescence,” Neurochemical Research, vol. 29, no. 3, pp. 617–628, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Remacle, M. Raes, O. Toussaint, P. Renard, and G. Rao, “Low levels of reactive oxygen species as modulators of cell function,” Mutation Research/DNAging, vol. 316, no. 3, pp. 103–122, 1995. View at Publisher · View at Google Scholar · View at Scopus
  32. N. Li and M. Karin, “Is NF-kappaB the sensor of oxidative stress?” The FASEB Journal, vol. 13, no. 10, pp. 1137–1143, 1999. View at Google Scholar · View at Scopus
  33. Y. Kabe, K. Ando, S. Hirao, M. Yoshida, and H. Handa, “Redox regulation of NF-κB activation: distinct redox regulation between the cytoplasm and the nucleus,” Antioxidants and Redox Signaling, vol. 7, no. 3-4, pp. 395–403, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. P. A. Baeuerle and D. Baltimore, “Nf-κB: ten years after,” Cell, vol. 87, no. 1, pp. 13–20, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Wang, X. Zhang, and J. J. Li, “The role of NF-κβ in the regulation of cell stress responses,” International Immunopharmacology, vol. 2, no. 11, pp. 1509–1520, 2002. View at Publisher · View at Google Scholar
  36. M. Barkett and T. D. Gilmore, “Control of apoptosis by Rel/NF-κB transcription factors,” Oncogene, vol. 18, no. 49, pp. 6910–6924, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Kucharczak, M. J. Simmons, Y. Fan, and C. Gélinas, “To be, or not to be: NF-kappaB is the answer—role of Rel/NF-kappaB in the regulation of apoptosis,” Oncogene, vol. 22, no. 56, pp. 8961–8982, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Sharma, R. L. Salisbury, E. I. Maurer, S. M. Hussain, and C. E. W. Sulentic, “Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line,” Nanoscale, vol. 5, no. 9, pp. 3747–3756, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. I. M. M. Paino, V. S. Marangoni, C. de Oliveira Rde, L. M. G. Antunes, and V. Zucolotto, “Cyto and genotoxicity of gold nanoparticles in human hepatocellular carcinoma and peripheral blood mononuclear cells,” Toxicology Letters, vol. 215, no. 2, pp. 119–125, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. J. J. Li, S.-L. Lo, C.-T. Ng et al., “Genomic instability of gold nanoparticle treated human lung fibroblast cells,” Biomaterials, vol. 32, no. 23, pp. 5515–5523, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. M. V. Botuyan, J. Lee, I. M. Ward et al., “Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair,” Cell, vol. 127, no. 7, pp. 1361–1373, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. R. A. DiTullio Jr., T. A. Mochan, M. Venere et al., “53BP1 functions in a ATM-dependent checkpoint pathway that is constitutively activated in human cancer,” Nature Cell Biology, vol. 4, no. 12, pp. 998–1002, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. B. Wang, S. Matsuoka, P. B. Carpenter, and S. J. Elledge, “53BP1, a mediator of the DNA damage checkpoint,” Science, vol. 298, no. 5597, pp. 1435–1438, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Silverman, H. Takai, S. B. C. Buonomo, F. Eisenhaber, and T. de Lange, “Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint,” Genes and Development, vol. 18, no. 17, pp. 2108–2119, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. S. Difilippantonio, E. Gapud, N. Wong et al., “53BP1 facilitates long-range DNA end-joining during V(D)J recombination,” Nature, vol. 456, no. 7221, pp. 529–533, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. L. S. Fink, M. Roell, E. Caiazza et al., “53BP1 contributes to a robust genomic stability in human fibroblasts,” Aging, vol. 3, no. 9, pp. 836–845, 2011. View at Google Scholar · View at Scopus