Electroencephalographic Changes Associated with Antinociceptive Actions of Lidocaine, Ketamine, Meloxicam, and Morphine Administration in Minimally Anaesthetized Dogs
Table 4
Pre- and posttreatment absolute values (mean ± SE) Ptot (µV2) with their percentage change (mean values) at various stimulation times across treatment groups.
Treatment
Before treatment
% change
5 min
% change
20 min
% change
40 min
% change
Ptot (KLD)
Before stimulation
8.17 ± 1.08c
10.71 ± 0.84a
10.41 ± 1.42a
9.18 ± 1.22bc
After stimulation
6.44 ± 0.52d
17.54
10.02 ± 1.22ab
12.42
8.07 ± 1.79c
25.11
6.76 ± 0.9d
26.96
Ptot (LLD)
Before stimulation
9.01 ± 0.94a
8.17 ± 0.73ab
8.52 ± 0.68ab
7.8 ± 0.76cb
After stimulation
8.29 ± 0.85ab
19.8
6.69 ± 0.85d
19.04
8.1 ± 1.35ab
37.04
7.1 ± 0.83dc
23.6
Ptot (MRP)
Before stimulation
7.78 ± 0.65ab
8.51 ± 1.11a
7.86 ± 0.66ab
7.77 ± 0.73ab
After stimulation
6.29 ± 0.63c
7.06
8.49 ± 1.01a
14.92
7.04 ± 0.89bc
17.36
7.02 ± 0.59bc
16.32
Ptot (MLX)
Before stimulation
9.04 ± 1.32a
9.28 ± 1.1a
8.57 ± 1.15ab
8.19 ± 0.92ab
After stimulation
7.86 ± 1.52bc
17.22
7.08 ± 0.76c
23.04
6.88 ± 0.67c
22.02
7.04 ± 0.87c
14.27
Means within a row and column in each treatment group followed by different letters are significantly different at (). MF = median frequency. KLD = ketamine loading dose. LLD = lidocaine loading dose. MRP = morphine. MLX = meloxicam.