Production of Monoclonal Antibodies in Plants for Cancer Immunotherapy

Table 1

Comparison of heterologous bioexpression systems.

Expression systems	Yeast	Insects	Mammalian cells	Plants
Production cost	Medium	Medium to high	High	Low
Maintaining cost	Cheap	Expensive	Expensive	Cheap
Protein yield	High	Medium to high	Medium to high	High
Gene size restriction	Unknown	Unknown	Limited	Not limited
Therapeutic risk	Unknown	Unknown	Yes	Unknown
Glycosylation	High mannose	Mannose terminal	Correct	Plant specific
Safety	Unknown	Medium	Medium	High
Time required	Medium	Medium	High	Medium