Production of Monoclonal Antibodies in Plants for Cancer Immunotherapy

Table 4

Transgenic plants used in the production of therapeutic antibodies.

Target	Transgenic plants	Antibodies	Application and specificity	Reference
Virus	Soybean	IgG against HSV-2	Treatment for HSV	[19]
Virus	Tobacco	IgG against rabies virus	Treatment for rabies virus	[10, 20]
Virus	Tobacco	IgG against Ebola virus	Treatment for Ebola virus	[21, 22]
Virus	Tobacco	IgG against HIV	Treatment for HIV	[23]
Virus	Tobacco	IgG against RSV	Treatment for RSV	[24]
Virus	Tobacco	IgG against WNV	Treatment for West Nile virus	[25]
Cancer	Tobacco	ScFv against CEA	Tumor marker and clinical test	[26]
Cancer	Rice	ScFv against CEA	Tumor marker and clinical test	[27]
Cancer	Cereals	ScFv against CEA	Tumor marker and clinical test	[28]
Cancer	Tobacco	IgG against tumor antigen Lewis Y	Treatment for breast cancer	[29]
Cancer	Tobacco	IgG against tumor antigen GA733-2	Treatment for colon cancer	[18, 30]
Bacteria	Tobacco	IgA against S. mutans	Prevention of dental caries	[31, 32]
Bacteria	Tobacco	IgG against S. mutans	Prevention of dental caries	[33]
Bacteria	Tobacco	Hybrid IgA-G	Anthrax	[34]

HSV: herpes simplex virus; HIV: human immunodeficiency virus; RSV: human respiratory syncytial virus; WNV: West Nile virus; and CEA: carcinoembryonic antigen.