Research Article
Preformulation Studies for Generic Omeprazole Magnesium Enteric Coated Tablets
Table 5
Moisture content in samples in conditions A, B, and C.
| | Conditions |
A (room temperature, plastic bottle closed) |
B (climatic chamber, plastic bottle opened) | C (oven, plastic bottle closed) |
| | Days | 3 | 8 | 30 | 60 | 90 | 3 | 8 | 30 | 60 | 90 | 3 | 8 | 30 | 60 | 90 | | Samples | | | | | | | | | | | | | | | | | Omep. Mg | 4.5 | 5.5 | 7.9 | 1.4 | 2.8 | 6.1 | 6.4 | 5.6 | 5.4 | 7 | 2.6 | 5.6 | 6.8 | 2.8 | 4.2 | | Omep. Mg: SLS | 2.1 | 3.9 | 4.2 | 2.6 | 2.8 | 5.7 | 6.8 | 3.8 | 4.1 | 6.8 | 2.7 | 5.6 | 5.5 | 1.4 | 2.8 | | Omep. Mg: lactose | 2.5 | 1.4 | 3.8 | 2.7 | 2.7 | 6.9 | 6.6 | 10.5 | 3.8 | 4 | 2.8 | 5.6 | 4.2 | 4.2 | 10.8 | | Omep. Mg: Avicel PH 101 | 3.9 | 5.6 | 4.2 | 4.2 | 2.8 | 6.7 | 6.8 | 8 | 7 | 6.6 | 2.7 | 5.1 | 5.7 | 4.1 | 5.5 | | Omep. Mg: starch | 5.6 | 8.3 | 6.8 | 5.6 | 5.4 | 10.1 | 6.7 | 12.9 | 8.9 | 5.4 | 5.6 | 7.5 | 6.8 | 2.8 | 2.8 | | Omep. Mg: water aerosil | 2.7 | 6.7 | 5 | 5.5 | 4.2 | 7.1 | 7 | 7.6 | 5.3 | 6.2 | 2.9 | 5.4 | 6.7 | 4.1 | 6.8 | | Omep. Mg: Mg stearate | 1.3 | 4 | 5.2 | 4.2 | 1.4 | 4 | 4.1 | 9 | 4.2 | 7 | 3.7 | 2.8 | 8.8 | 4.2 | 4.1 | | Omep. Mg: all excipients | 4.1 | 6.8 | 5.6 | 5.5 | 4.2 | 5.4 | 5.7 | 8.2 | 7 | 7.1 | 5.2 | 7.1 | 14.1 | 4.2 | 6.1 |
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