The Interplay between Cyclic AMP, MAPK, and NF-κB Pathways in Response to Proinflammatory Signals in Microglia

Figure 8

Cell signaling schema illustrating the proposed interactions between the PDE-PKA-cyclic AMP, MAPK, and NF-κB pathways in regulating proinflammatory microglial cell phenotype and function in response to TNF-α. This cell diagram shows the proposed interactions between PDE-PKA-cyclic AMP, MAPK, and NF-κB pathways in the cytoplasm and nucleus of microglia in response to TNF-α stimulation. These interactions control the proinflammatory gene program that alters microglial cell phenotype and function.