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BioMed Research International
Volume 2015, Article ID 308505, 7 pages
http://dx.doi.org/10.1155/2015/308505
Review Article

Ocular Blood Flow and Normal Tension Glaucoma

1Shenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China
2Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China

Received 22 May 2015; Accepted 1 July 2015

Academic Editor: Goji Tomita

Copyright © 2015 Ning Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Plange, A. Remky, and O. Arend, “Colour Doppler imaging and fluorescein filling defects of the optic disc in normal tension glaucoma,” British Journal of Ophthalmology, vol. 87, no. 6, pp. 731–736, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. H. J. Kaiser, A. Schoetzau, D. Stumpfig, and J. Flammer, “Blood-flow velocities of the extraocular vessels in patients with high- tension and normal-tension primary open-angle glaucoma,” American Journal of Ophthalmology, vol. 123, no. 3, pp. 320–327, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Grunwald, J. Piltz, S. M. Hariprasad, and J. DuPont, “Optic nerve and choroidal circulation in glaucoma,” Investigative Ophthalmology & Visual Science, vol. 39, no. 12, pp. 2329–2336, 1998. View at Google Scholar · View at Scopus
  4. A. Alm and A. Bill, “Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues,” Experimental Eye Research, vol. 15, no. 1, pp. 15–29, 1973. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Caprioli and A. L. Coleman, “Blood pressure, perfusion pressure, and glaucoma,” The American Journal of Ophthalmology, vol. 149, no. 5, pp. 704–712, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Harris and B. Wirostko, “Cerebral blood flow in glaucoma patients,” Journal of Glaucoma, vol. 22, no. 5, pp. S46–S48, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Schmetterer and G. Garhofer, “How can blood flow be measured?” Survey of Ophthalmology, vol. 52, supplement 2, pp. S134–S138, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Plange, M. Kaup, A. Remky, and K. O. Arend, “Prolonged retinal arteriovenous passage time is correlated to ocular perfusion pressure in normal tension glaucoma,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 246, no. 8, pp. 1147–1152, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. E. C. Koch, K. O. Arend, M. Bienert, A. Remky, and N. Plange, “Arteriovenous passage times and visual field progression in normal tension glaucoma,” The Scientific World Journal, vol. 2013, Article ID 726912, 6 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. H. F. A. Duijm, T. J. T. P. van den Berg, and E. L. Greve, “A comparison of retinal and choroidal hemodynamics in patients with primary open-angle glaucoma and normal-pressure glaucoma,” American Journal of Ophthalmology, vol. 123, no. 5, pp. 644–656, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Martinez and M. Sanchez, “Ocular blood flow in glaucoma,” British Journal of Ophthalmology, vol. 92, no. 9, p. 1301, 2008. View at Google Scholar
  12. A. Martinez and M. Sanchez, “Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma,” Eye, vol. 22, no. 4, pp. 515–520, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Galassi, A. Sodi, F. Ucci, G. Renieri, B. Pieri, and M. Baccini, “Ocular hemodynamics and glaucoma prognosis: a color Doppler imaging study,” Archives of Ophthalmology, vol. 121, no. 12, pp. 1711–1715, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Yamazaki and S. M. Drance, “The relationship between progression of visual field defects and retrobulbar circulation in patients with glaucoma,” American Journal of Ophthalmology, vol. 124, no. 3, pp. 287–295, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. Z. Butt, C. O'Brien, G. McKillop, P. Aspinall, and P. Allan, “Color Doppler imaging in untreated high- and normal-pressure open-angle glaucoma,” Investigative Ophthalmology and Visual Science, vol. 38, no. 3, pp. 690–696, 1997. View at Google Scholar · View at Scopus
  16. N. Yüksel, Y. Anik, Ö. Altintaş, I. Onur, Y. Cağlar, and A. Demirci, “Magnetic resonance imaging of the brain in patients with pseudoexfoliation syndrome and glaucoma,” Ophthalmologica, vol. 220, no. 2, pp. 125–130, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. G. A. Stroman, W. C. Stewart, K. C. Golnik, J. K. Cure, and R. E. Olinger, “Magnetic resonance imaging in patients with low tension glaucoma,” Archives of Ophthalmology, vol. 113, no. 2, pp. 168–172, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Ong, A. Farinelli, F. Billson, M. Houang, and M. Stern, “Comparative study of brain magnetic resonance imaging findings in patients with low-tension glaucoma and control subjects,” Ophthalmology, vol. 102, no. 11, pp. 1632–1638, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Suzuki, A. Tomidokoro, M. Araie et al., “Visual field damage in normal-tension glaucoma patients with or without ischemic changes in cerebral magnetic resonance imaging,” Japanese Journal of Ophthalmology, vol. 48, no. 4, pp. 340–344, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Sugiyama, M. Araie, C. E. Riva, L. Schmetterer, and S. Orgul, “Use of laser speckle flowgraphy in ocular blood flow research,” Acta Ophthalmologica, vol. 88, no. 7, pp. 723–729, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Shiga, K. Omodaka, H. Kunikata et al., “Waveform analysis of ocular blood flow and the early detection of normal tension glaucoma,” Investigative Ophthalmology and Visual Science, vol. 54, no. 12, pp. 7699–7706, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Flammer and M. Mozaffarieh, “What is the present pathogenetic concept of glaucomatous optic neuropathy?” Survey of Ophthalmology, vol. 52, supplement 2, pp. S162–S173, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Mozaffarieh and J. Flammer, “New insights in the pathogenesis and treatment of normal tension glaucoma,” Current Opinion in Pharmacology, vol. 13, no. 1, pp. 43–49, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Suzuki, A. Iwase, M. Araie et al., “Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study,” Ophthalmology, vol. 113, no. 9, pp. 1613–1617, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Konieczka, R. Ritch, C. Traverso et al., “Flammer syndrome,” The EPMA Journal, vol. 5, no. 1, article 11, 2014. View at Publisher · View at Google Scholar
  26. M. Pache, B. Dubler, and J. Flammer, “Peripheral vasospasm and nocturnal blood pressure dipping—two distinct risk factors for glaucomatous damage?” European Journal of Ophthalmology, vol. 13, no. 3, pp. 260–265, 2003. View at Google Scholar · View at Scopus
  27. Y.-D. Kim, S. B. Han, K. H. Park et al., “Risk factors associated with optic disc haemorrhage in patients with normal tension glaucoma,” Eye, vol. 24, no. 4, pp. 567–572, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Drange, D. R. Anderson, and M. Schulzer, “Risk factors for progression of visual field abnormalities in normal-tension glaucoma,” American Journal of Ophthalmology, vol. 131, no. 6, pp. 699–708, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Flammer, M. Pache, and T. Resink, “Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye,” Progress in Retinal and Eye Research, vol. 20, no. 3, pp. 319–349, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. J. F. Beltrame, S. Sasayama, and A. Maseri, “Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and caucasian patients,” Journal of the American College of Cardiology, vol. 33, no. 6, pp. 1442–1452, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Cursiefen, M. Wisse, S. Cursiefen, A. Jünemann, P. Martus, and M. Korth, “Migraine and tension headache in high-pressure and normal-pressure glaucoma,” The American Journal of Ophthalmology, vol. 129, no. 1, pp. 102–104, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. J. J. Corbett, C. D. Phelps, P. Eslinger, and P. R. Montague, “The neurologic evaluation of patients with low-tension glaucoma,” Investigative Ophthalmology & Visual Science, vol. 26, no. 8, pp. 1101–1104, 1985. View at Google Scholar
  33. R. L. Furlanetto, C. G. De Moraes, C. C. Teng et al., “Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study,” American Journal of Ophthalmology, vol. 157, no. 5, pp. 945.e1–952.e1, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. S. D. Silberstein, “Migraine,” The Lancet, vol. 363, no. 9406, pp. 381–391, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. M. C. Kruit, L. J. Launer, M. D. Ferrari, and M. A. Van Buchem, “Infarcts in the posterior circulation territory in migraine: the population-based MRI CAMERA study,” Brain, vol. 128, no. 9, pp. 2068–2077, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. D. R. Anderson, “Glaucoma, capillaries and pericytes. 1. Blood flow regulation,” Ophthalmologica, vol. 210, no. 5, pp. 257–262, 1996. View at Publisher · View at Google Scholar · View at Scopus
  37. S. M. Drance and I. S. Begg, “Sector hemorrhage: a probable acute ischemic disc change in chronic simple glaucoma,” Canadian Journal of Ophthalmology, vol. 5, no. 2, pp. 137–141, 1970. View at Google Scholar
  38. D. C. Broadway and S. M. Drance, “Glaucoma and vasospasm,” British Journal of Ophthalmology, vol. 82, no. 8, pp. 862–870, 1998. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Orgul, H. J. Kaiser, J. Flammer, and P. Gasser, “Systemic blood pressure and capillary blood-cell velocity in glaucoma patients: a preliminary study,” European Journal of Ophthalmology, vol. 5, no. 2, pp. 88–91, 1995. View at Google Scholar · View at Scopus
  40. M. E. Charlson, C. G. de Moraes, A. Link et al., “Nocturnal systemic hypotension increases the risk of glaucoma progression,” Ophthalmology, vol. 121, no. 10, pp. 2004–2012, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Tian and Y.-H. Liu, “Normal-tension glaucoma and Alzheimer's disease: retinal vessel signs as a possible common underlying risk factor,” Medical Hypotheses, vol. 77, no. 3, p. 466, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. J. C. de la Torre, “Alzheimer disease as a vascular disorder: nosological evidence,” Stroke, vol. 33, no. 4, pp. 1152–1162, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. J. Flammer, S. Orgül, V. P. Costa et al., “The impact of ocular blood flow in glaucoma,” Progress in Retinal and Eye Research, vol. 21, no. 4, pp. 359–393, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. T. Sugiyama, K. Utsunomiya, H. Ota, Y. Ogura, I. Narabayashi, and T. Ikeda, “Comparative study of cerebral blood flow in patients with normal-tension glaucoma and control subjects,” American Journal of Ophthalmology, vol. 141, no. 2, pp. 394–396, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Wostyn, “Normal-tension glaucoma and Alzheimer's disease: hypothesis of a possible common underlying risk factor,” Medical Hypotheses, vol. 67, no. 5, pp. 1255–1256, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Kountouras, C. Zavos, E. Gavalas, M. Boziki, D. Chatzopoulos, and P. Katsinelos, “Normal-tension glaucoma and Alzheimer's disease: Helicobacter pylori as a possible common underlying risk factor,” Medical Hypotheses, vol. 68, no. 1, pp. 228–229, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Kountouras, C. Zavos, and D. Chatzopoulos, “Primary open-angle glaucoma: pathophysiology and treatment,” The Lancet, vol. 364, no. 9442, pp. 1311–1312, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Prunte-Glowazki and J. Flammer, “Ocular vasospasm. 4: clinical examples,” Klinische Monatsblätter für Augenheilkunde, vol. 198, no. 5, pp. 415–418, 1991. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Gasser and O. Meienberg, “Finger microcirculation in classical migraine. A video-microscopic study of nailfold capillaries,” European Neurology, vol. 31, no. 3, pp. 168–171, 1991. View at Publisher · View at Google Scholar · View at Scopus
  50. C. D. Phelps and J. J. Corbett, “Migraine and low-tension glaucoma. A case-control study,” Investigative Ophthalmology & Visual Science, vol. 26, no. 8, pp. 1105–1108, 1985. View at Google Scholar · View at Scopus
  51. K. Gugleta, C. Zawinka, I. Rickenbacher et al., “Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity,” Investigative Ophthalmology and Visual Science, vol. 47, no. 9, pp. 4034–4041, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Kochkorov, K. Gugleta, C. Zawinka, R. Katamay, J. Flammer, and S. Orgul, “Short-term retinal vessel diameter variability in relation to the history of cold extremities,” Investigative Ophthalmology & Visual Science, vol. 47, no. 9, pp. 4026–4033, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. K. Nitta, “Disc hemorrhage is a sign of progression in normal-tension glaucoma,” Journal of Glaucoma, vol. 21, no. 4, article 276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. M. C. Grieshaber, T. Terhorst, and J. Flammer, “The pathogenesis of optic disc splinter haemorrhages: a new hypothesis,” Acta Ophthalmologica Scandinavica, vol. 84, no. 1, pp. 62–68, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. A. S. Hafez, R. Bizzarro, D. Descovich, and M. R. Lesk, “Correlation between finger blood flow and changes in optic nerve head blood flow following therapeutic intraocular pressure reduction,” Journal of Glaucoma, vol. 14, no. 6, pp. 448–454, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. Y. Delaney, T. E. Walshe, and C. O'Brien, “Vasospasm in glaucoma: clinical and laboratory aspects,” Optometry and Vision Science, vol. 83, no. 7, pp. 406–414, 2006. View at Publisher · View at Google Scholar · View at Scopus
  57. J. Choi, J. Jeong, H.-S. Cho, and M. S. Kook, “Effect of nocturnal blood pressure reduction on circadian fluctuation of mean ocular perfusion pressure: a risk factor for normal tension glaucoma,” Investigative Ophthalmology and Visual Science, vol. 47, no. 3, pp. 831–836, 2006. View at Publisher · View at Google Scholar · View at Scopus
  58. J. Choi, K. H. Kim, J. Jeong, H.-S. Cho, C. H. Lee, and M. S. Kook, “Circadian fluctuation of mean ocular perfusion pressure is a consistent risk factor for normal-tension glaucoma,” Investigative Ophthalmology & Visual Science, vol. 48, no. 1, pp. 104–111, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. J. Choi, J. R. Lee, Y. Lee et al., “Relationship between 24-hour mean ocular perfusion pressure fluctuation and rate of paracentral visual field progression in normal-tension glaucoma,” Investigative Ophthalmology and Visual Science, vol. 54, no. 9, pp. 6150–6157, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Flammer, K. Konieczka, and A. J. Flammer, “The primary vascular dysregulation syndrome: implications for eye diseases,” The EPMA Journal, vol. 4, no. 1, article 14, 2013. View at Google Scholar
  61. K. Konieczka, S. Fränkl, M. G. Todorova, and P. B. Henrich, “Unstable oxygen supply and glaucoma,” Klinische Monatsblätter für Augenheilkunde, vol. 231, no. 2, pp. 121–126, 2014. View at Publisher · View at Google Scholar · View at Scopus
  62. J. Flammer, “The glaucomatous optic neuropathy: a reperfusion damage,” Klinische Monatsblätter für Augenheilkunde, vol. 218, no. 5, pp. 290–291, 2001. View at Publisher · View at Google Scholar · View at Scopus
  63. M. Mozaffarieh, M. C. Grieshaber, and J. Flammer, “Oxygen and blood flow: players in the pathogenesis of glaucoma,” Molecular Vision, vol. 14, pp. 224–233, 2008. View at Google Scholar · View at Scopus
  64. M. Cellini, E. Strobbe, C. Gizzi, N. Balducci, P. G. Toschi, and E. C. Campos, “Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma,” Life Sciences, vol. 91, no. 13-14, pp. 699–702, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. Y. Z. Shoshani, A. Harris, M. M. Shoja et al., “Endothelin and its suspected role in the pathogenesis and possible treatment of glaucoma,” Current Eye Research, vol. 37, no. 1, pp. 1–11, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. O. Golubnitschaja, K. Yeghiazaryan, R. Liu et al., “Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients,” Journal of Glaucoma, vol. 13, no. 1, pp. 66–72, 2004. View at Publisher · View at Google Scholar · View at Scopus
  67. D. Moore, A. Harris, D. Wudunn, N. Kheradiya, and B. Siesky, “Dysfunctional regulation of ocular blood flow: a risk factor for glaucoma?” Clinical Ophthalmology, vol. 2, no. 4, pp. 849–861, 2008. View at Publisher · View at Google Scholar
  68. H. Schempp and E. F. Elstner, “Free radicals in the pathogenesis of ocular diseases,” in Nitric Oxide and Endothelin in the Pathogenesis of Glaucoma, I. O. Haefliger and J. Flammer, Eds., pp. 112–135, Lippincott-Raven, Philadelphia, Pa, USA, 1998. View at Google Scholar
  69. J. A. Adams, “Endothelium and cardiopulmonary resuscitation,” Critical Care Medicine, vol. 34, supplement 12, pp. S458–S465, 2006. View at Publisher · View at Google Scholar · View at Scopus
  70. N. Toda and M. Nakanishi-Toda, “Nitric oxide: ocular blood flow, glaucoma, and diabetic retinopathy,” Progress in Retinal and Eye Research, vol. 26, no. 3, pp. 205–238, 2007. View at Publisher · View at Google Scholar · View at Scopus
  71. C. Napoli, F. de Nigris, and W. Palinski, “Multiple role of reactive oxygen species in the arterial wall,” Journal of Cellular Biochemistry, vol. 82, no. 4, pp. 674–682, 2001. View at Publisher · View at Google Scholar · View at Scopus
  72. G. M. Rubanyi and M. A. Polokoff, “Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology,” Pharmacological Reviews, vol. 46, no. 3, pp. 325–415, 1994. View at Google Scholar · View at Scopus
  73. N. Y. Lee, H.-Y. L. Park, C. K. Park, and M. D. Ahn, “Analysis of systemic endothelin-1, matrix metalloproteinase-9, macrophage chemoattractant protein-1, and high-sensitivity C-reactive protein in normal-tension glaucoma,” Current Eye Research, vol. 37, no. 12, pp. 1121–1126, 2012. View at Publisher · View at Google Scholar · View at Scopus
  74. T. Sugiyama, S. Moriya, H. Oku, and I. Azuma, “Association of endothelin-1 with normal tension glaucoma: clinical and fundamental studies,” Survey of Ophthalmology, vol. 39, supplement 1, pp. S49–S56, 1995. View at Publisher · View at Google Scholar · View at Scopus
  75. K. Polak, A. Luksch, B. Frank, K. Jandrasits, E. Polska, and L. Schmetterer, “Regulation of human retinal blood flow by endothelin-1,” Experimental Eye Research, vol. 76, no. 5, pp. 633–640, 2003. View at Publisher · View at Google Scholar · View at Scopus
  76. S. Orgul, G. A. Cioffi, D. R. Bacon, and E. M. Van Buskirk, “An endothelin-1 induced model of chronic optic nerve ischemia in rhesus monkeys,” Journal of Glaucoma, vol. 5, no. 2, pp. 135–138, 1996. View at Google Scholar
  77. C. Buckley, P. W. F. Hadoke, E. Henry, and C. O'Brien, “Systemic vascular endothelial cell dysfunction in normal pressure glaucoma,” British Journal of Ophthalmology, vol. 86, no. 2, pp. 227–232, 2002. View at Publisher · View at Google Scholar · View at Scopus
  78. Y. Tamaki, M. Araie, K. Tomita, M. Nagahara, and A. Tomidokoro, “Effect of topical beta-blockers on tissue blood flow in the human optic nerve head,” Current Eye Research, vol. 16, no. 11, pp. 1102–1110, 1997. View at Publisher · View at Google Scholar · View at Scopus
  79. Y. Tamaki, M. Araie, K. Tomita, and M. Nagahara, “Effect of topical betaxolol on tissue circulation in the human optic nerve head,” Journal of Ocular Pharmacology and Therapeutics, vol. 15, no. 4, pp. 313–321, 1999. View at Publisher · View at Google Scholar · View at Scopus
  80. Y. Tamaki, M. Nagahara, M. Araie, K. Tomita, S. Sandoh, and A. Tomidokoro, “Topical latanoprost and optic nerve head and retinal circulation in humans,” Journal of Ocular Pharmacology and Therapeutics, vol. 17, no. 5, pp. 403–411, 2001. View at Publisher · View at Google Scholar · View at Scopus
  81. S. Tsuda, Y. Yokoyama, N. Chiba et al., “Effect of topical tafluprost on optic nerve head blood flow in patients with myopic disc type,” Journal of Glaucoma, vol. 22, no. 5, pp. 398–403, 2013. View at Publisher · View at Google Scholar · View at Scopus
  82. K. Ishii, A. Tomidokoro, M. Nagahara et al., “Effects of topical latanoprost on optic nerve head circulation in rabbits, monkeys, and humans,” Investigative Ophthalmology and Visual Science, vol. 42, no. 12, pp. 2957–2963, 2001. View at Google Scholar · View at Scopus