BioMed Research International / 2015 / Article / Tab 3

Research Article

Characterization of Multidrug Resistant Extended-Spectrum Beta-Lactamase-Producing Escherichia coli among Uropathogens of Pediatrics in North of Iran

Table 3

Association between gene expression and antimicrobial nonsusceptibility in ESBL-producing E. coli.

Antimicrobial agentsTEM CTX VEB SHV
PositiveNegativePositiveNegativePositiveNegativePositiveNegative

Cephalosporins
 Cefepime38 (77.6%)42 (82.4%)23 (82.1%)57 (79.2%)6 (75%)74 (80.4%)38 (86.4%)42 (75%)
 Cefixime49 (100%)50 (98%)27 (96.4%)72 (100%)8 (100%)91 (98.9%)43 (97.7%)56 (100%)
 Ceftriaxone29 (59.2%)41 (80.4%22 (78.6%)48 (66.7%)4 (50%)66 (71.7%)33 (75%)37 (66.7%)
 Ceftazidime22 (44.9%)23 (45.1%)11 (39.3%)34 (47.2%)6 (75%39 (42.4%)17 (38.6%)28 (50%)
 Ceftizoxime34 (69.4%)39 (76.5%)23 (82.1%)50 (69.4%)6 (75%)67 (72.8%)32 (12.7%)41 (73.2%)
 Cefotaxime21 (42.9%)32 (62.7%18 (64.3%)35 (48.6%)5 (62.5%)48 (52.2%)21 (47.7%) 32 (57.1%)
Carbapenems
 Imipenem14 (28.6%)20 (39.2%)11 (39.3%)23 (31.9%)3 (37.5%)31 (33.7%)15 (34.1%)19 (34%)
 Meropenem12 (24.5%)21 (42.2%)9 (32.1%)24 (33.3%)3 (37.5%)30 (32.6%)13 (29.5%)20 (35.7%)
Aminoglycosides
 Amikacin14 (28.6%)28 (54.9%13 (46.4%)29 (40.3%)3 (37.5%)39 (42.4%)24 (54.5%18 (32%)
 Gentamicin21 (42.9%)28 (54.9%)14 (50%)35 (48.6%)5 (62.5%)44 (47.8%)27 (61.4%22 (39.3%)
Others
 Ciprofloxacin34 (69.4%)42 (82.4%)21 (75%)55 (76.4%)5 (62.5%)71 (77.2%)39 (88.6%37 (66%)
 Colistin39 (79.6)43 (84.3%)23 (82.1%)59 (81.9%)6 (75%)76 (82.6%)38 (86.4%)44 (78.6%)
 TMP/SXT34 (69.4%)38 (74.5%)21 (75%)51 (70.8%)4 (50%)68 (73.9%)29 (65.9%)43 (76.8%)
 Pip/TBZ29 (59.2%)29 (59.2%)15 (53.6%)43 (59.7%)4 (50%)4 (50%)25 (56.8% )33 (59%)

: resistance, : intermediate, : sensitive, and ESBL: extended-spectrum beta-lactamase.
Significant differences ( < 0.05).