Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling

Figure 1

(a, b) Heat map of significantly upregulated genes (a) or downregulated genes (b) in primary cortical neurons treated with isoflurane. Diagrams depicting differentially expressed genes were grouped into distinct categories based on the function of encoded proteins shown on the left. (c) Quantitative pathway analysis using gene set enrichment showed the enrichment of FAS signaling in isoflurane-treated primary cortical neurons. (d) Heat map of microarray analysis demonstrated that the FAS signaling related transcripts were upregulated, including FAS and its ligand, FASL.

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