Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling

Figure 5

(a) Isoflurane prolonged the escape latency (EL) of wild type neonatal mice compared with the wild type control group. The effects of time and group differences between the two groups were significant; . (b and d) Isoflurane did not prolong the EL of either FAS-knockout or FASL-knockout mice compared with wild type neonatal mice treated with isoflurane. The effects of time and group differences between the two groups were significant. (c and e) EL of the wild type control group and isoflurane-treated FAS- and FASL-knockout mice were not significantly different. (f) Isoflurane significantly reduced the platform crossing times of wild type neonatal mice compared with wild type control mice and isoflurane-treated FAS- and FASL-knockout mice.

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