Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility

Table 5

Comparisons of genotype data between presence/absence of cancer history stratified by smoking-related phenotypes.

	Genotype			Genotypic model		Dominant model			Recessive model
	TT	TC	CC			OR (95% CI)^a			OR (95% CI)^a
Smoking history
Ever-smokers
Cancer	17	65	40	3.281788	0.19381	1.017 (0.659–1.570)	0.005743	0.93959	0.617 (0.349–1.090)	2.805891	0.09392
Control	79	175	126
Never-smokers
Cancer	16	50	25	1.234473	0.53943	1.299 (0.782–2.159)	1.022436	0.31194	0.966 (0.530–1.761)	0.012551	0.91080
Control	68	184	124
Smoking period (year)
Long (≥44)
Cancer	13	31	24	0.392140	0.82195	1.226 (0.635–2.365)	0.181513	0.67008	1.226 (0.635–2.365)	0.341154	0.55916
Control	43	86	62
Short (<44)
Cancer	4	34	16	5.917681	0.05188	1.226 (0.635–2.365)	0.369160	0.54346	0.338 (0.115–0.996)	4.191842	0.04062
Control	36	88	64
CPD^b
High (>20)
Cancer	9	19	12	1.526609	0.46612	1.642 (0.743–3.630)	1.514011	0.21853	1.194 (0.484–2.946)	0.147578	0.70086
Control	18	36	38
Low (≤20)
Cancer	8	46	28	5.512995	0.06351	0.849 (0.504–1.428)	0.382380	0.53633	0.402 (0.184–0.880)	5.491155	0.01911^†
Control	61	139	88
Brinkman (smoking) index
High (>700)
Cancer	12	33	24	1.322869	0.51611	0.961 (0.536–1.723)	0.017720	0.89410	0.671 (0.330–1.365)	1.223659	0.26864
Control	43	76	61
Low (≤700)
Cancer	5	32	16	3.103819	0.21184	1.130 (0.586–2.181)	0.133278	0.71506	0.469 (0.174–1.261)	2.341073	0.12600
Control	36	97	65

Odds ratio (95% confidence interval).
^bCigarettes smoked per day.
Significant association between the minor T allele of the SNP and noncancer status (present or past illness) in the recessive model () in subjects whose smoking duration is short.
^†Significant association between the minor T allele of the SNP and noncancer status (present or past illness) in the recessive model () in subjects whose CPD rate is low.