Review Article
New Insights into Glomerular Parietal Epithelial Cell Activation and Its Signaling Pathways in Glomerular Diseases
Table 2
Signaling pathways involved in glomerular parietal epithelial cells activation.
| | Human | Animal model |
| Notch | FSGS, DN [46] | Collapsing FSGS transgenic mice model [44], FSGS SCID mice model [46] | Wnt/β-catenin | N/A | Conditional β-catenin −/− mice [57] | HB-EGF/EGFR | CGN, FSGS [60, 61] | Anti-GBM induced CGN mice model [62] | CXCR4/SDF-1 | CGN [63] | MWF rat with CGN [64], VHL −/− mice [65] | Ang II//AT1 receptor | Proliferative CGN [64] | MWF rat with CGN [75] | LAT2 | N/A | Anti-GBM induced CGN rat model [78] | SSeCKS/cyclin D | N/A | SSeCKS −/− mice [82] |
|
|