A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress

Figure 4

Stochastic simulation of cell population with respect to ER stress. (a) Single cell treatment with (left panel) low (S0 = 1) and (right panel) high (S0 = 5) level of ER stress. (b) The probability distributions of autophagy and apoptosis were studied during various treatments by doing 50 independent simulations. The averaged behavior of a cell population is computed with respect to (left panel) low (S0 = 1) and (right panel) high (S0 = 5) level of ER stress. (c) Probability distributions of the strength of ER stressor in cell populations. 50 single cell simulations were done at any different levels of ER stressor from S0 = 1 to 10. The percentage of autophagic (left panel) and apoptotic (right panel) cells was checked after 240 min long treatment.

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