Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015 (2015), Article ID 319589, 12 pages
http://dx.doi.org/10.1155/2015/319589
Research Article

A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress

Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Tűzoltó Utca 37-47, Budapest 1094, Hungary

Received 3 December 2014; Revised 6 March 2015; Accepted 25 March 2015

Academic Editor: Andrea Orsi

Copyright © 2015 Marianna Holczer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. A. J. Alberts, J. Lewis, m. Raff, K. Roberts, and P. Walter, Molecular Biology of the Cell, Garland Science, New York, NY, USA, 4th edition, 2002.
  2. M. C. Maiuri, E. Zalckvar, A. Kimchi, and G. Kroemer, “Self-eating and self-killing: crosstalk between autophagy and apoptosis,” Nature Reviews Molecular Cell Biology, vol. 8, no. 9, pp. 741–752, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Appenzeller-Herzog and M. N. Hall, “Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling,” Trends in Cell Biology, vol. 22, no. 5, pp. 274–282, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Görlach, P. Klappa, and T. Kietzmann, “The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control,” Antioxidants & Redox Signaling, vol. 8, no. 9-10, pp. 1391–1418, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. W. Wickner and R. Schekman, “Protein translocation across biological membranes,” Science, vol. 310, no. 5753, pp. 1452–1456, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Zhang and R. J. Kaufman, “Protein folding in the endoplasmic reticulum and the unfolded protein response,” Handbook of Experimental Pharmacology, vol. 172, pp. 69–91, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Malhi and R. J. Kaufman, “Endoplasmic reticulum stress in liver disease,” Journal of Hepatology, vol. 54, no. 4, pp. 795–809, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Csala, É. Margittai, and G. Bánhegyi, “Redox control of endoplasmic reticulum function,” Antioxidants & Redox Signaling, vol. 13, no. 1, pp. 77–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Bánhegyi, A. Benedetti, M. Csala, and J. Mandl, “Stress on redox,” FEBS Letters, vol. 581, no. 19, pp. 3634–3640, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Tabas and D. Ron, “Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress,” Nature Cell Biology, vol. 13, no. 3, pp. 184–190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Bánhegyi, P. Baumeister, A. Benedetti et al., “Endoplasmic reticulum stress,” Annals of the New York Academy of Sciences, vol. 1113, pp. 58–71, 2007. View at Publisher · View at Google Scholar
  12. S. Bernales, F. R. Papa, and P. Walter, “Intracellular signaling by the unfolded protein response,” Annual Review of Cell and Developmental Biology, vol. 22, pp. 487–508, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Hetz, “The unfolded protein response: controlling cell fate decisions under ER stress and beyond,” Nature Reviews Molecular Cell Biology, vol. 13, no. 2, pp. 89–102, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Walter and D. Ron, “The unfolded protein response: from stress pathway to homeostatic regulation,” Science, vol. 334, no. 6059, pp. 1081–1086, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Xu, B. Bailly-Maitre, and J. C. Reed, “Endoplasmic reticulum stress: cell life and death decisions,” The Journal of Clinical Investigation, vol. 115, no. 10, pp. 2656–2664, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Ogata, S.-I. Hino, A. Saito et al., “Autophagy is activated for cell survival after endoplasmic reticulum stress,” Molecular and Cellular Biology, vol. 26, no. 24, pp. 9220–9231, 2006. View at Publisher · View at Google Scholar
  17. M. Høyer-Hansen and M. Jäättelä, “Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium,” Cell Death and Differentiation, vol. 14, no. 9, pp. 1576–1582, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Levine and G. Kroemer, “Autophagy in the pathogenesis of disease,” Cell, vol. 132, no. 1, pp. 27–42, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Ravikumar, S. Sarkar, J. E. Davies et al., “Regulation of mammalian autophagy in physiology and pathophysiology,” Physiological Reviews, vol. 90, no. 4, pp. 1383–1435, 2010. View at Publisher · View at Google Scholar
  20. S. Fulda, A. M. Gorman, O. Hori, and A. Samali, “Cellular stress responses: cell survival and cell death,” International Journal of Cell Biology, vol. 2010, Article ID 214074, 23 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. I. Tabas and D. Ron, “Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress,” Nature Cell Biology, vol. 13, no. 3, pp. 184–190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Li and J. Yuan, “Caspases in apoptosis and beyond,” Oncogene, vol. 27, no. 48, pp. 6194–6206, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. J. F. Kerr, A. H. Wyllie, and A. R. Currie, “Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics,” British Journal of Cancer, vol. 26, no. 4, pp. 239–257, 1972. View at Publisher · View at Google Scholar · View at Scopus
  24. S. J. Riedl and Y. Shi, “Molecular mechanisms of caspase regulation during apoptosis,” Nature Reviews Molecular Cell Biology, vol. 5, no. 11, pp. 897–907, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. X. Saelens, N. Festjens, L. V. Walle, M. van Gurp, G. van Loo, and P. Vandenabeele, “Toxic proteins released from mitochondria in cell death,” Oncogene, vol. 23, no. 16, pp. 2861–2874, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. I. G. Ganley, P.-M. Wong, N. Gammoh, and X. Jiang, “Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest,” Molecular Cell, vol. 42, no. 6, pp. 731–743, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. O. Larsson, M. Carlberg, and A. Zetterberg, “Selective killing induced by an inhibitor of N-linked glycosylation,” Journal of Cell Science, vol. 106, part 1, pp. 299–307, 1993. View at Google Scholar · View at Scopus
  28. S. Jiang, S. C. Chow, P. Nicotera, and S. Orrenius, “Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca2+-ATPase inhibitor thapsigargin,” Experimental Cell Research, vol. 212, no. 1, pp. 84–92, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. O. Kapuy, P. K. Vinod, and G. Bánhegyi, “mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress—an experimental and modeling study,” FEBS Open Bio, vol. 4, pp. 704–713, 2014. View at Publisher · View at Google Scholar
  30. C. M. Oslowski and F. Urano, “Measuring ER stress and the unfolded protein response using mammalian tissue culture system,” Methods in Enzymology, vol. 490, pp. 71–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. J. M. Gump and A. Thorburn, “Autophagy and apoptosis: what is the connection?” Trends in Cell Biology, vol. 21, no. 7, pp. 387–392, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Gordy and Y.-W. He, “The crosstalk between autophagy and apoptosis: where does this lead?” Protein & Cell, vol. 3, no. 1, pp. 17–27, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Djavaheri-Mergny, M. C. Maiuri, and G. Kroemer, “Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1,” Oncogene, vol. 29, no. 12, pp. 1717–1719, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Wirawan, L. V. Walle, K. Kersse et al., “Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria,” Cell Death & Disease, vol. 1, no. 1, article e18, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. O. Kapuy, P. K. Vinod, J. Mandl, and G. Bánhegyi, “A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis,” Molecular BioSystems, vol. 9, no. 2, pp. 296–306, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. O. Kapuy, B. Lizák, I. Stiller, and G. Bánhegyi, “A systems biological perspective of cellular stress-directed programmed cell death,” Computational Molecular Bioscience, vol. 4, no. 1, pp. 28–34, 2014. View at Publisher · View at Google Scholar
  37. Y. Xu, J. Yuan, and M. M. Lipinski, “Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis,” Autophagy, vol. 9, no. 9, pp. 1418–1430, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Kaplan and L. Glass, Understanding Nonlinear Dynamics, Springer, New York, NY, USA, 1995.
  39. J. J. Tyson, K. C. Chen, and B. Novak, “Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell,” Current Opinion in Cell Biology, vol. 15, no. 2, pp. 221–231, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. S. H. Strogatz, Nonlinear Dynamics and Chaos, Addison-Wesley, Reading, Mass, USA, 1994.
  41. O. Kapuy and G. Bánhegyi, “Depletion of luminal pyridine nucleotides in the endoplasmic reticulum activates autophagy with the involvement of mTOR pathway,” BioMed Research International, vol. 2013, Article ID 942431, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. S. L. Spencer, S. Gaudet, J. G. Albeck, J. M. Burke, and P. K. Sorger, “Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis,” Nature, vol. 459, no. 7245, pp. 428–432, 2009. View at Publisher · View at Google Scholar · View at Scopus