The Role of Epigenetics in Arterial Calcification

Table 1

miRNAs involved in the regulation of arterial calcification.

miRNAs	Observation	Ref.
miR-125b	Target SP7, inhibiting osteogenic transdifferentiation of VSMCs	[88, 89]
miR-133a	Target Runx2, inhibiting the osteogenic differentiation of VSMCs	[92]
miR-135a/762/714/712	Targets NCX1, PMCA1, and NCKX4, promoting VSMCs calcification	[94]
miR-204	Target Runx2, inhibiting VSMCs calcification	[93]
miR-221/222	Targets Enpp1 and Pit-1, contributing to arterial calcification	[95]
miR-223	Targets Mef2c and RhoB, inducing VSMCs migration and calcification	[96]
miR-29a/b	Target ADAMTS-7, inhibiting VSMCs calcification	[90]
miR-30b/30c	Target Runx2, inhibiting VSMCs calcification	[91]