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BioMed Research International
Volume 2015 (2015), Article ID 321740, 9 pages
http://dx.doi.org/10.1155/2015/321740
Review Article

Lesser-Known Molecules in Ovarian Carcinogenesis

1Department of Morpho-Functional Sciences, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iaşi, Romania
2Department of Mother and Child Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iaşi, Romania

Received 9 January 2015; Revised 14 June 2015; Accepted 7 July 2015

Academic Editor: Fatima Mechta-Grigoriou

Copyright © 2015 Ludmila Lozneanu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Currently, the deciphering of the signaling pathways brings about new advances in the understanding of the pathogenic mechanism of ovarian carcinogenesis, which is based on the interaction of several molecules with different biochemical structure that, consequently, intervene in cell metabolism, through their role as regulators in proliferation, differentiation, and cell death. Given that the ensemble of biomarkers in OC includes more than 50 molecules the interest of the researchers focuses on the possible validation of each one’s potential as prognosis markers and/or therapeutic targets. Within this framework, this review presents three protein molecules: ALCAM, c-FLIP, and caveolin, motivated by the perspectives provided through the current limited knowledge on their role in ovarian carcinogenesis and on their potential as prognosis factors. Their structural stability, once altered, triggers the initiation of the sequences characteristic for ovarian carcinogenesis, through their role as modulators for several signaling pathways, contributing to the disruption of cellular junctions, disturbance of pro-/antiapoptotic equilibrium, and alteration of transmission of the signals specific for the molecular pathways. For each molecule, the text is built as follows: (i) general remarks, (ii) structural details, and (iii) particularities in expression, from different tumors to landmarks in ovarian carcinoma.