BioMed Research International / 2015 / Article / Fig 4

Research Article

Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke

Figure 4

THC increased the free radical leak in brain mitochondria. Effect of  M of THC on the free radical leak (FRL). FRL corresponds to the fraction of electrons out of sequence which reduces O2 to ROS in the respiratory chain (the percent of free radical leak) instead of reaching cytochrome oxidase. THC: tetrahydrocannabinol. Control FRL without THC (white graph) and FRL after THC exposure (black graph).

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