Amniotic Mesenchymal Stem Cells Can Enhance Angiogenic Capacity via MMPs In Vitro and In Vivo

Figure 4

Development of HUVEC tube formation under serum-free 3D fibrin matrices. HUVECs were labeled with GFP and cocultured with MSCs (hAMSCs and BMMSCs). HUVEC-sprouting could be found as early as 12 h (indicated by arrows) and obviously at 48 h (indicated by arrows). Lumen-like structures rounded by HUVECs were indicated by arrows in (l) and (r). Microscopic view is . The length of HUVEC-sprouting and average EC vessel area were showed in (s) and (t).

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