Review Article
The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection
Figure 2
Activation of different signaling pathways for host cell invasion by T. cruzi II (a) and T. cruzi I (b). (a) The ligation gp82-receptor activates a protein tyrosine kinase and a parasite phospholipase C, which releases Ca2+ from inositol-1,4,5-triphosphate (IP3) sensitive reservoirs, possibly the endoplasmic reticulum. (b) The gp35/50-receptor binding appears to stimulate adenylate cyclase activity that seems to participate in Ca2+ release from acidocalcisomes.
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| (b) |