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BioMed Research International
Volume 2015 (2015), Article ID 325029, 8 pages
http://dx.doi.org/10.1155/2015/325029
Review Article

Scaffolds from Surgically Removed Kidneys as a Potential Source of Organ Transplantation

1Department of Transplantology, General, Vascular and Plastic Surgery, Clinical Hospital of Poznan University of Medical Sciences, 60-780 Poznan, Poland
2Clinical Hospital of Poznan University of Medical Sciences, 60-780 Poznan, Poland

Received 7 December 2014; Revised 18 January 2015; Accepted 18 January 2015

Academic Editor: Giuseppe Lucarelli

Copyright © 2015 Marek Karczewski and Tomasz Malkiewicz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

End stage renal disease (ESRD) is a common disease, which relates to nearly 600 million people in the total population. What is more, it seems to be a crucial problem from the epidemiological point of view. These facts lead to a further necessity of renal replacement therapy development connected with rising expenditures for the health care system. The aim of kidney tissue engineering is to develop and innovate methods of obtaining renal extracellular matrix (ECM) scaffolds derived from kidney decellularization. Recently, progress has been made towards developing a functional kidney graft in vitro on demand. In fact, decellularized tissues constitute ideal natural scaffolds, due to the preservation of native ECM architecture, as well as of cell-ECM binding domains critical in promoting cell attachment, migration, and proliferation. One of the potential sources of the natural scaffolds is the kidney, which cannot be transplanted immediately after excision.