Two-Year Accelerated Corneal Cross-Linking Outcome in Patients with Progressive Keratoconus
Table 1
Clinical parameters in qualifying examination and control tests at 7 days, 14 days, and 3, 12, and 24 months after accelerated cross-linking in patients with progressive keratoconus.
Pre-CXL (range)
7 days (range)
value pre-CXL, 7 days
14 days (range)
value pre-CXL, 14 days
3 months (range)
value pre-CXL, 3 months
12 months (range)
value pre-CXL, 12 months
24 months (range)
value pre-CXL, 24 months
UCVA ()
0,24 ± 0,15 (0,05–0,5)
0,07 ± 0,05 (0,004–0,2)
= 0.000
0,15 ± 0,1 (0,04–0,3)
= 0.004
0,19 ± 0,12 (0,06–0,4)
= 0.008
0,23 ± 0,13 (0,06–0,4)
> 0.05
0,24 ± 0,14 (0,05–0,5)
> 0.05
BSCVA ()
0,48 ± 0,2 (0,15–0,8)
0,16 ± 0,15 (0,004–0,6)
= 0.000
0,33 ± 0,22 (0,08–0,8)
= 0.001
0,45 ± 0,22 (0,1–0,8)
= 0.043
0,47 ± 0,19 (0,125–0,8)
> 0.05
0,48 ± 0,21 (0,125–0,8)
> 0.05
Corneal topographic astigmatism (D)
2,16 ± 1,05 (0,9–4,5)
2,19 ± 0,96 (0,3–3,3)
> 0.05
2,25 ± 1,15 (0,9–4,8)
> 0.05
2,21 ± 1,12 (0,5–4,3)
> 0.05
1,91 ± 1,08 (0,5–4,4)
> 0.05
2,00 ± 1,04 (0,75–4,3)
> 0.05
Sim (D)
47,61 ± 2,07 (43,3–51,2)
47,66 ± 2,06 (43,7–50,7)
> 0.05
47,51 ± 2,55 (44,0–53,3)
> 0.05
47,07 ± 2,41 (43,4–51,5)
> 0.05
46,28 ± 3,08 (37,2–49,4)
> 0.05
46,96 ± 1,93 (43,5–49,7)
> 0.05
Sim (D)
45,39 ± 1,71 (41,7–48,2)
45,14 ± 2,44 (39,7–48,6)
> 0.05
45,05 ± 2,78 (39,2–48,5)
> 0.05
45,14 ± 2,44 (39,4–48,2)
> 0.05
44,64 ± 3,58 (33,5–47,4)
> 0.05
45,04 ± 2,3 (39,5–47,1)
> 0.05
Corneal eccentricity index
0,82 ± 0,24 (0,26–1,16)
0,79 ± 0,36 (0,03–1,12)
> 0.05
0,82 ± 0,31 (0,15–1,3)
> 0.05
0,84 ± 0,24 (0,22–1,17)
> 0.05
0,82 ± 0,29 (0,01–1,17)
> 0.05
0,81 ± 0,25 (0,27–1,23)
> 0.05
Pachymetry in central point (μm) in USP
509 ± 22 (476–567)
582 ± 41 (525–681)
= 0.000
533 ± 49 (470–630)
> 0.05
502 ± 26 (458–552)
> 0.05
492 ± 23 (446–535)
= 0.001
512 ± 28 (476–579)
> 0.05
Pachymetry in apex point (μm) in USP
452 ± 28 (412–521)
509 ± 22 (476–567)
< 0.05
489 ± 33 (435–560)
> 0.05
448 ± 33 (409–537)
> 0.05
450 ± 33 (409–535)
> 0.05
448 ± 32 (420–530)
> 0.05
BSCVA: best spectacle-corrected visual acuity; CXL: corneal collagen cross-linking; D: diopters; : logarithm of the minimum angle of resolution; pre-: before treatment; Sim : simulated keratometry in the steepest meridian; Sim : simulated keratometry in the flattest meridian; UCVA: uncorrected visual acuity; USP: ultrasound pachymetry; data are mean ± standard deviation.
