Research Article
The Effect of Young Age in Hormone Receptor Positive Breast Cancer
Table 1
Preoperative and pathologic characteristics in young women compared to older women.
| | Variable | ≤40 years
() | >40 years
() | value |
| | Age, median (IQR) | 36 (32–39) | 58 (50–67) | 0.00 | | Breast cancer family history (%) | 24 (44.4) | 238 (38.7) | 0.51 | | BRCA1/2 tested (%) | 26 (48.1) | 74 (12.0) | <0.01 | | BRCA1/2 positive | 11 | 13 | 0.02 | | Neoadjuvant treatment (%) | 5 (9.3) | 37 (6.0) | 0.43 | | Grade (%) | | | | | Low | 2 (3.7) | 130 (21.1) | <0.01 | | Intermediate | 24 (44.4) | 345 (56.1) | | High | 27 (50.0) | 136 (22.1) | | Differentiation (%) | | | | | Well | 7 (13.0) | 237 (38.7) | <0.01 | | Moderate | 27 (50.0) | 262 (42.6) | | Poor | 20 (37.0) | 105 (17.1) | | Lymphovascular invasion (%) | 20 (37.0) | 136 (22.1) | 0.04 | | Receptor status | | | | | ER+ (%) | 52 (96.3) | 609 (99.0) | 0.13 | | ER% staining, median (IQR) | 80 (60–95) | 90 (80–95) | <0.01 | | PR+ (%) | 45 (83.3) | 514 (83.6) | 0.99 | | PR% staining, median (IQR) | 55 (10–90) | 60 (10–90) | 0.92 | | Ki67, median (IQR) | 12 (7–17) | 12 (7–17) | 0.99 | | Luminal subtype (%) | | | | | Luminal A | 20 (37.0) | 358 (58.2) | <0.01 | | Luminal B | 34 (63.0) | 257 (41.8) | | Tumor stage (%) | | | | | T1 | 25 (46.3) | 329 (53.5) | 0.55 | | T2 | 22 (40.7) | 205 (33.3) | | T3 | 6 (11.1) | 56 (9.1) | | T4 | 1 (1.9) | 25 (4.1) | | Nodal stage (%) | | | | | N0 | 25 (46.3) | 375 (61.0) | <0.01 | | N1 | 20 (37.0) | 155 (25.2) | | N2 | 9 (16.7) | 36 (5.9) | | N3 | 0 (0) | 21 (3.4) | | Stage (%) | | | | | I | 15 (27.8) | 266 (43.3) | 0.07 | | II | 27 (50.0) | 259 (42.1) | | III | 12 (22.2) | 90 (14.6) |
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ER: estrogen receptor.
PR: progesterone receptor.
IQR: interquartile range.
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