Review Article

Luminex and Other Multiplex High Throughput Technologies for the Identification of, and Host Response to, Environmental Triggers of Type 1 Diabetes

Figure 1

Susceptibility genes and environmental triggers in development and progression of type 1 diabetes. In genetically susceptible individuals, different classes of environmental exposures such as diet, infection, and pollutants lead to increase in peripheral and mucosal inflammation causing leaky gut and aberrant immune reaction towards pancreatic β-cells.