Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus

Figure 4

Golem dissolution results for nonbuffered generic batch80 and its reference product Lipitor. The plots show dissolution behavior measured in separate compartments, as well as cumulative profile showing the amount of drug dissolved in the whole apparatus including the amount gradually transferred from ileum into the collection canister. The terminal decrease of dissolved amount in individual compartments was caused by transfer of portions of the medium into the following compartment, or into the collection canister in case of ileum.