Research Article
Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus
Table 2
Intravenous administration simulation parameters.
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—logarithm of the octanol-water partition coefficient; pKa—dissociation constant; B/P—blood-to-plasma partition coefficient; fu—fraction unbound in plasma; —maximum reaction rate achieved by the system; —substrate concentration at which the reaction rate is half of . |