Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype
The main phenomena of macrophage reprogramming. (a) The phenomenon of an amplified macrophage response to both the reprogramming factor (direct amplification) and another factor (cross amplification). (b) The phenomenon of reciprocal suppression of the alternate phenotype. (c) The phenomenon of a cascade activation of the reprogramming mechanisms. (d) The feedback phenomenon.
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