Research Article

Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein Are Associated with Increased Carotid Intima-Media Thickness: A Cross-Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors

Table 3

Correlation coefficients between cIMT and characteristics of evaluated the groups.

Baseline variablecIMT (mm)

Age, years0.587<0.001
Disease duration, years0.0180.88
DAS28, units0.3500.05
TC, mg/dL0.7200.002
Tg, mg/dL0.3970.001
HDL-c, mg/dL−0.5950.02
LDL-c, mg/dL0.3320.007
VLDL-c, mg/dL0.2670.03
AIP: TC/HDL-c0.7160.001
ESR, mm/h−0.1370.38
RF, IU/mL0.2140.04
CRP, mg/L0.799<0.001
TNF, pg/mL0.6420.001
IL-6, pg/mL0.751<0.001
Anti-CCP, U/mL0.5130.001

cIMT, carotid intima-media thickness; RA, rheumatoid arthritis; DAS28, disease activity score; TC, total cholesterol; Tg, triglycerides; HDL-c, high density lipoprotein cholesterol; LDL-c, low density lipoprotein cholesterol; VLDL-c, very low density lipoprotein cholesterol; AIP, atherogenic index of plasma; ESR, erythrocyte sedimentation rate; RF, rheumatoid factor; CRP, C-reactive protein; TNF, tumor necrosis factor alpha; IL-6, interleukin-6; anti-CCP, anticyclic citrullinated peptide antibodies.