Lunasin Inhibits Cell Proliferation via Apoptosis and Reduces the Production of Proinflammatory Cytokines in Cultured Rheumatoid Arthritis Synovial Fibroblasts

Figure 1

Lunasin inhibits the proliferation of RA synovial fibroblasts. Cells were synchronized and incubated with lunasin at various concentrations for 24, 48, and 72 h, respectively. Then, the cell samples were harvested and subjected to count the number by crystal violet staining. The IC₅₀ was  μM after 48 h incubation. Data were expressed as the percentage relative to the untreated control samples, and each value was expressed as mean ± SD for three independent experiments by GraphPad Prism Software Version 5.0. was considered a significant difference when compared with the control.