The Roles of SNF2/SWI2 Nucleosome Remodeling Enzymes in Blood Cell Differentiation and Leukemia
Table 2
ICGC data for the SNF2 enzymes.
SNF2 enzyme
Mutations in malignant lymphoma
Mutations in AML
Mutations in CLL
SMARCA4/Brg1
15/44 (34%)
2/75 (2.7%)
—
SMARCA2/Brm
8/44 (18%)
3/75 (4.0%)
1/109 (0.92%)
SMARCA5/SNF2H
1/44 (2.3%)
—
—
SMARCA1/SNF2L
5/44 (11%)
—
—
CHD1
2/44 (4.5%)
2/75 (2.7%)
—
CHD2
5/44 (11%)
4/75 (5.3%)
5/109 (4.6%)
CHD3
—
4/75 (5.3%)
—
CHD4
5/44 (11%)
3/75 (4.0%)
—
CHD5
1/44 (2.3%)
3/75 (4.0%)
—
CHD6
6/44 (14%)
4/75 (5.3%)
—
CHD7
8/44 (18%)
1/75 (1.3%)
—
CHD8
3/44 (6.8%)
3/75 (4.0%)
—
CHD9
9/44 (20%)
3/75 (4.0%)
—
HELLS
4/44 (9.1%)
3/75 (4.0%)
—
CHD1L
3/44 (6.8%)
1/75 (1.3%)
—
SRCAP
2/44 (4.5%)
1/75 (1.3%)
EP400
3/44 (6.8%)
2/75 (2.7%)
—
INO80
7/44 (16%)
1/75 (1.3%)
—
SMARCAD1/Etl1
3/44 (6.8%)
1/75 (1.3%)
RAD54B
2/44 (4.5%)
3/75 (4.0%)
—
RAD54L
4/44 (9.1%)
1/75 (1.3%)
—
ATRX
—
2/75 (2.7%)
—
Arip4
ND
ND
ND
SMARCA3
3/44 (6.8%)
2/75 (2.7%)
—
TTF2
2/44 (4.5%)
1/75 (1.2%)
—
SHPRH
8/44 (18%)
3/75 (4.0%)
1/109 (0.92%)
BTAF1
7/44 (16%)
2/75 (2.7%)
—
ERCC6
2/44 (4.5%)
2/75 (2.7%)
—
SMARCAL1
2/44 (4.5%)
—
—
ZRANB3
14/44 (32%)
3/75 (4.0%)
—
The ICGC data portal (https://dcc.icgc.org/) was queried with all 30 human SNF2 helicase genes (October 2014). The frequency and percent of mutations in the patients are indicated for each gene. ND = not determined.
