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BioMed Research International
Volume 2015, Article ID 349172, 5 pages
http://dx.doi.org/10.1155/2015/349172
Review Article

Contrast-Enhanced Ultrasound in the Diagnosis of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: Controversy over the ASSLD Guideline

Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China

Received 8 August 2014; Revised 13 January 2015; Accepted 13 January 2015

Academic Editor: Ayache Bouakaz

Copyright © 2015 Le-Hang Guo and Hui-Xiong Xu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Bruix and M. Sherman, “Management of hepatocellular carcinoma,” Hepatology, vol. 42, no. 5, pp. 1208–1236, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. L.-D. Chen, H.-X. Xu, X.-Y. Xie et al., “Intrahepatic cholangiocarcinoma and hepatocellular carcinoma: differential diagnosis with contrast-enhanced ultrasound,” European Radiology, vol. 20, no. 3, pp. 743–753, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Li, X. Zhang, K.-S. Ma et al., “Dynamic enhancing vascular pattern of intrahepatic peripheral cholangiocarcinoma on contrast-enhanced ultrasound: the influence of chronic hepatitis and cirrhosis,” Abdominal Imaging, vol. 38, no. 1, pp. 112–119, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Claudon, C. F. Dietrich, B. I. Choi et al., “Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver—update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS,” Ultrasound in Medicine & Biology, vol. 39, no. 2, pp. 187–210, 2013. View at Publisher · View at Google Scholar
  5. M. Claudon, D. Cosgrove, T. Albrecht et al., “Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS)—update 2008,” Ultraschall in der Medizin, vol. 29, no. 1, pp. 28–44, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Seitz, T. Bernatik, D. Strobel et al., “Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI—a prospective comparison in 269 patients,” Ultraschall in der Medizin, vol. 31, no. 5, pp. 492–499, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Seitz, D. Strobel, T. Bernatik et al., “Contrast-Enhanced ultrasound (CEUS) for the characterization of focal liver lesions—prospective comparison in clinical practice: CEUS vs. CT (DEGUM Multicenter Trial) parts of this manuscript were presented at the Ultrasound Dreiländertreffen 2008, Davos,” Ultraschall in der Medizin, vol. 30, no. 4, pp. 383–389, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Li, W. Wang, H. Ding et al., “Value of contrast-enhanced sonography in the diagnosis of peripheral intrahepatic cholangiocarcinoma,” Journal of Clinical Ultrasound, vol. 39, no. 8, pp. 447–453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. W. T. Kong, W. P. Wang, W. W. Zhang, Y. D. Qiu, H. Ding, and B. J. Huang, “Contribution of contrast-enhanced sonography in the detection of intrahepatic cholangiocarcinoma,” Journal of Ultrasound in Medicine, vol. 33, no. 2, pp. 215–220, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. H.-X. Xu, L.-D. Chen, L.-N. Liu, Y.-F. Zhang, L.-H. Guo, and C. Liu, “Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination,” British Journal of Radiology, vol. 85, no. 1016, pp. 1029–1037, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. L.-D. Chen, H.-X. Xu, X.-Y. Xie et al., “Enhancement patterns of intrahepatic cholangiocarcinoma: comparison between contrast-enhanced ultrasound and contrast-enhanced CT,” British Journal of Radiology, vol. 81, no. 971, pp. 881–889, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. R. E. Carraway and D. E. Cochrane, “Enhanced vascular permeability is hypothesized to promote inflammation-induced carcinogenesis and tumor development via extravasation of large molecular proteins into the tissue,” Medical Hypotheses, vol. 78, no. 6, pp. 738–743, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. J. A. Nagy, A. M. Dvorak, and H. F. Dvorak, “Vascular hyperpermeability, angiogenesis, and stroma generation,” Cold Spring Harbor Perspectives in Medicine, vol. 2, no. 2, Article ID a006544, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. S. J. Kim, Y. Lee, N. Y. Kim et al., “Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability,” Oncogene, vol. 32, no. 31, pp. 3638–3647, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. Rosen and M. D. Schnall, “Dynamic contrast-enhanced magnetic resonance imaging for assessing tumor vascularity and vascular effects of targeted therapies in renal cell carcinoma,” Clinical Cancer Research, vol. 13, no. 2, pp. 770s–776s, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. C. A. Cuenod, L. Fournier, D. Balvay, and J.-M. Guinebretière, “Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment,” Abdominal Imaging, vol. 31, no. 2, pp. 188–193, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. M. D'Onofrio, F. Vecchiato, V. Cantisani et al., “Intrahepatic peripheral cholangiocarcinoma (IPCC): comparison between perfusion ultrasound and CT imaging,” Radiologia Medica, vol. 113, no. 1, pp. 76–86, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Omata, L. A. Lesmana, R. Tateishi et al., “Asian pacific association for the study of the liver consensus recommendations on hepatocellular carcinoma,” Hepatology International, vol. 4, no. 2, pp. 439–474, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Kudo, N. Izumi, N. Kokudo et al., “Management of hepatocellular carcinoma in Japan: consensus-based clinical practice guidelines proposed by the Japan society of hepatology (JSH) 2010 updated version,” Digestive Diseases, vol. 29, no. 3, pp. 339–364, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Bruix and M. Sherman, “Management of hepatocellular carcinoma: an update,” Hepatology, vol. 53, no. 3, pp. 1020–1022, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Vilana, A. Forner, L. Bianchi et al., “Intrahepatic peripheral cholangiocarcinoma in cirrhosis patients may display a vascular pattern similar to hepatocellular carcinoma on contrast-enhanced ultrasound,” Hepatology, vol. 51, no. 6, pp. 2020–2029, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Vallin, N. Sturm, G. Lamblin et al., “Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants,” Clinical Transplantation, vol. 27, no. 3, pp. 403–409, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. W. Bohle, P. U. Clemens, T. Heubach, and W. G. Zoller, “Contrast-enhanced ultrasound (CEUS) for differentiating between hepatocellular and cholangiocellular carcinoma,” Ultraschall in der Medizin, vol. 33, no. 7, pp. E191–E195, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Galassi, M. Iavarone, S. Rossi et al., “Patterns of appearance and risk of misdiagnosis of intrahepatic cholangiocarcinoma in cirrhosis at contrast enhanced ultrasound,” Liver International, vol. 33, no. 5, pp. 771–779, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. A. P. Barreiros, F. Piscaglia, and C. F. Dietrich, “Contrast enhanced ultrasound for the diagnosis of hepatocellular carcinoma (HCC): comments on AASLD guidelines,” Journal of Hepatology, vol. 57, no. 4, pp. 930–932, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Giorgio, L. Montesarchio, and V. Giorgio, “Misdiagnosis of intrahepatic cholangiocarcinoma in cirrhosis at contrast-enhanced ultrasound: a real new clinical entity or just an exaggerated fear?” Liver International, vol. 33, no. 10, p. 1608, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Y. Jang, M. Y. Kim, S. W. Jeong et al., “Current consensus and guidelines of contrast enhanced ultrasound for the characterization of focal liver lesions,” Clinical and Molecular Hepatology, vol. 19, no. 1, pp. 1–16, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. C. F. Dietrich, X. W. Cui, B. Boozari, M. Hocke, and A. Ignee, “Contrast-enhanced ultrasound (CEUS) in the diagnostic algorithm of hepatocellular and cholangiocellular carcinoma, comments on the AASLD guidelines,” Ultraschall in der Medizin, vol. 33, no. 1, pp. S57–S66, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Li, M. X. Yuan, K. S. Ma et al., “Detailed analysis of temporal features on contrast enhanced ultrasound may help differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma in cirrhosis,” PLoS ONE, vol. 9, no. 5, Article ID e98612, 2014. View at Publisher · View at Google Scholar
  30. J. M. Hudson, R. Karshafian, and P. N. Burns, “Quantification of flow using ultrasound and microbubbles: a disruption replenishment model based on physical principles,” Ultrasound in Medicine and Biology, vol. 35, no. 12, pp. 2007–2020, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. E. Amarteifio, S. Wormsbecher, M. Krix et al., “Dynamic contrast-enhanced ultrasound and transient arterial occlusion for quantification of arterial perfusion reserve in peripheral arterial disease,” European Journal of Radiology, vol. 81, no. 11, pp. 3332–3338, 2012. View at Publisher · View at Google Scholar · View at Scopus