High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy
Table 2
Prevalence of thyroid dysfunctionsb,c.
BMI (Kg/m2)
Total
Overt hypothyroidism (%)
Subclinical hypothyroidism (%)
Isolated hypothyroxinemia (%)
TPOAb positive (%)
TgAb positive (%)
Total
6303
63 (1.0)
203 (3.2)
149 (2.4)
578 (9.2)
790 (12.5)
<18.5
870
2 (0.2)
29 (3.3)
11 (1.3)
58 (6.7)
94 (10.8)
18.5–24.9
4547
42 (0.9)
141 (3.1)
87 (1.9)
402 (8.8)
564 (12.4)
25.0–29.9
796
16 (2.0)
26 (3.3)
40 (5.0)
97 (12.2)
114 (14.3)
≥30.0
90
3 (3.3)
7 (7.8)
11 (12.2)
21 (23.3)
18 (20.0)
P value
<0.001
0.101
<0.001
<0.001
0.025
valuea
<0.001
0.340
<0.001
<0.001
0.004
value for trend. was considered as a significant difference. cThe diagnostic standards for thyroid abnormalities were according to the pregnant specific reference ranges of the 4th–8th gestational weeks.