Heart Failure: Advanced Development in Genetics and Epigenetics

Table 4

Cardiomyopathy Genes and Associated Clinical Features.

Gene	DCM	HCM	ARVC	Inheritance	Location/role
Abcc9	X			AD	Potassium channel
ACTC1	X	X		AD	Sarcomere
ACTN2	X	X		AD	Z-disk
DES	X		X	AD	Intermediate filament
DSC2	X		X	AD	Desmosome
DSG2	X		X	AD	Desmosome
DSP	X		X	AD, AR	Desmosome
LAMP2	X	X		XL	Lysosome
LMNA			X	AD	Nuclear membrane
MYBPC3	X	X		AD	Sarcomere
MYH7	X	X	X	AD	Sarcomere
PKP2		X	X	AD	Desmosome
TNNC1	X	X		AD	Sarcomere
TNNI3	X	X		AD	Sarcomere
TNNT2	X	X		AD	Sarcomere
TTN	X	X	X	AD	Sarcomere