Review Article
Heart Failure: Advanced Development in Genetics and Epigenetics
Table 5
Main involved miRNAs in heart failure.
| MicroRNA | Expression in HF | Function in cardiac vascular system |
| 1 | Downregulated | Development and function of cardiac and skeletal muscle | 15/16 | Upregulated | Apoptosis induction | 21 | Upregulated | Induced in endothelial cells by shear stress; modulates the apoptosis and eNOS activity | 195 | Upregulated | Involved in myocyte hypertrophy and dilated cardiomyopathy | 199a | Upregulated | Essential for maintaining the cardiomyocytes size | 133 | Downregulated | Development and function of cardiac and skeletal muscle; Regulation of beta-adrenergic receptors | 23a | Upregulated | Involved in the regulation of cardiac hypertrophy | 320 | Upregulated | Involved in the regulation of cardiac ischemia injury | 208 | Upregulated | Stress-induced cardiac hypertrophy, Reduced β-MHC expression |
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