Prognostic Value of Homotypic Cell Internalization by Nonprofessional Phagocytic Cancer Cells

Figure 1

Cell-in-cell structures are found in different tumor tissues. (a) Representative image of an E-cadherin-labeled head and neck squamous cell carcinoma tissue microarray spot with numerous CIC structures and magnifications of indicated regions. (b) Representative images of E-cadherin-labeled head and neck cancer CIC structures. (c) Frequency of CIC structures in different cancer types. (d) Comparative frequency of CIC (A) in the tumor tissue of rectal and anal cancer patients, (B) in low-risk and high-risk HNSCC patients, (C) in the primary tumor of HNSCC tumors and the affected regional lymph nodes, (D) before and after neoadjuvant radiochemotherapy, and (E) in the central tumor area and invasive front of HNSCC. R(C)T: radiochemotherapy or radiotherapy.