Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility
Table 3
Interaction analysis between the variations of NFκB1 and IκBα on NPC risk.
Cases ( = 1590) IκBα: rs696 G>A
Controls ( = 1979) IκBα: rs696 G>A
Crude OR (95% CI)a
Adjusted OR (95% CI)a
GG + AG (%)
AA (%)
GG + AG (%)
AA (%)
AA versus GG + AG
AA versus GG + AG
NFκB1:
rs28362491 del/ins
del/del
204 (75.8)
65 (24.2)
331 (79.0)
88 (21.0)
1.20 (0.83–1.73)
1.24 (0.85–1.80)
del/ins
575 (74.8)
194 (25.2)
762 (80.2)
188 (19.8)
1.37 (1.09–1.72)
1.38 (1.09–1.74)
ins/ins
392 (71.0)
160 (29.0)
482 (79.0)
124 (21.0)
1.54 (1.18–2.01)
1.53 (1.17–2.02)
Combined genotypes
2.25 ×
del/ins + ins/ins
967 (73.2)
354 (26.8)
1244 (79.7)
316 (20.3)
1.44 (1.21–1.71)
1.45 (1.22–1.74)
ORs were adjusted for age, sex and smoking status, and alcohol use, family history of cancer in a logistic regression model. value of test for the multiplicative interaction between rs696 G>A genotypes and rs28362491 del/ins genotypes on cancer risk in logistic regression models.
