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BioMed Research International
Volume 2015, Article ID 362564, 6 pages
http://dx.doi.org/10.1155/2015/362564
Research Article

Twelve-Month Results of a Single or Multiple Dexamethasone Intravitreal Implant for Macular Edema following Uncomplicated Phacoemulsification

1Ophthalmology Unit, DAI Testa/Collo, Azienda Policlinico Umberto I, University of Rome “Sapienza”, Viale del Policlinico 155, 00161 Rome, Italy
2Ophthalmology Unit, Sant’Andrea Hospital, NESMOS Department, University of Rome “Sapienza”, Via di Grottarossa 1035-1039, 00189 Rome, Italy

Received 9 January 2015; Accepted 17 February 2015

Academic Editor: Francesco Piraino

Copyright © 2015 Solmaz Abdolrahimzadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The clinical efficacy of one or two intravitreal injections of a continued deliverance dexamethasone 700 μg implant in ten patients with persistent macular edema following uncomplicated phacoemulsification was evaluated. Complete ophthalmological examination and spectral domain optical coherence tomography were carried out. Follow-up was at day 7 and months 1, 2, 4, 6, 8, and 12. At baseline mean best corrected visual acuity was 62 Early Treatment Diabetic Retinopathy Study Chart letters, which showed statistically significant improvement at each follow-up, except at month 6, to reach 79 letters at month 12 (). Prior to treatment mean central foveal thickness was 622 μm, which showed statistically significant improvement at each follow-up to reach a mean value of 282 μm () at month 12. Five patients received a second dexamethasone implant at month 7. Two patients were excluded from the study at months 4 and 8. Intraocular pressure remained stable during the study period with the exception of mild increase in two patients requiring topical therapy. In conclusion there was statistically significant improvement of best corrected visual acuity and mean central foveal thickness with one or two intravitreal dexamethasone implants over 12 months.