Red Blood Cell Destruction in Autoimmune Hemolytic Anemia: Role of Complement and Potential New Targets for Therapy

Figure 1

The complement cascade, simplified. Only components relevant for this paper are shown. The lectin and alternative pathways, converging with the classical pathway at the C3 activation level, are indicated but not shown in detail. Physiological inhibitors and positive feedback loops are not shown. C: complement protein; MAC: membrane attack complex.